IBS Functional Boweldisorders
Irritable
Recurrent non specificbowel movements in the absence of
specific organic pathology
athophysiology
Heterogenous Multifactorial
Altered gastrointestinal motility T frequencyand or
irregularityof bowel
contractions
Eisceral hypersensitivity hyperalgesia Hypersensitivityof
afferentnerves
I
nerve
d painthreshold
endings fJ food inducespain
m intolerance gutto
songresponse of
minor stimuli
Aching
Altered permeability
of 91 mucosa
Tmotility smallfreqstool
d motility hardpellety
shifts
carbs
draws
water in metabolizedby
SMspasm al bacterial flora gas bloating
gutdysbiosis
, Increasedcolonicmotorpotential sigmoidmotoractivity
recto
upto3hrsaftereating
motilityindex
5HT containing Enterochromaffincells serotonergic
Brain gut interaction dysfunction Cingulatecortexactivation
Psychosocial behavioral factors
Vanilloid channels TRPV alsoimplicated
Narrison
Irritable
Recurrent non specificbowel movements in the absence of
specific organic pathology
athophysiology
Heterogenous Multifactorial
Altered gastrointestinal motility T frequencyand or
irregularityof bowel
contractions
Eisceral hypersensitivity hyperalgesia Hypersensitivityof
afferentnerves
I
nerve
d painthreshold
endings fJ food inducespain
m intolerance gutto
songresponse of
minor stimuli
Aching
Altered permeability
of 91 mucosa
Tmotility smallfreqstool
d motility hardpellety
shifts
carbs
draws
water in metabolizedby
SMspasm al bacterial flora gas bloating
gutdysbiosis
, Increasedcolonicmotorpotential sigmoidmotoractivity
recto
upto3hrsaftereating
motilityindex
5HT containing Enterochromaffincells serotonergic
Brain gut interaction dysfunction Cingulatecortexactivation
Psychosocial behavioral factors
Vanilloid channels TRPV alsoimplicated
Narrison
