BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, AUTACOIDS (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
AUTACOIDS-1
MCQs
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
1. The term “Autacoid” means:
A) Naturally occurring substances.
B) Synthesized, released, and metabolized locally within a tissue.
C) Have variable pharmacological actions and usually vasoactive.
D) All the above.
2. Which of the following is considered an Autacoid:
A) 5-hydroxy-trytamine.
B) Prostaglandin E2.
C) Angiotensin.
D) All the above.
3. Which of the following features is associated with Histamine as an autacoid:
A) Synthesized from Histidine.
B) Synthesized from Tryptophan.
C) Betazole is a synthetic analogue.
D) Both A & C may apply.
4. Histamine:
A) Synthesized by Histidine decarboxylase.
B) Stored in specialized intracellular granules in mast cells.
C) Mainly occurs as bound form together with heparin and protein.
D) All the above.
5. Histamine could be released by:
A) Proteolytic enzymes as trypsin in venoms and toxins.
B) Drugs which can displace histamine from tissues as morphine.
C) Antigens or allergens via immunological reaction on mast cell membrane.
D) All the above.
6. Which of the following drugs are associated with Histamine release:
A) Basic drugs as d-tubocurarine.
B) Acidic drugs as aspirin.
C) Both of them.
D) None of them.
Autacoid Pharmacology Surviving Revision
, BENHA UNIVERSITY, CREDIT HOURS SYSTEM
7. Labile or free form of Histamine occurs in little amounts could be released by histamine
liberators.
A) True.
B) False.
8. Which of the following statements is true regarding Histamine?
A) A biologic amine with a histaminopexic power.
B) Ineffective orally.
C) Cannot pass blood-brain barrier.
D) All the above may apply.
9. Which of the following receptors could be activated by Histamine?
A) H1 receptor on smooth muscles and sensory nerve endings.
B) H2 receptor on gastric glands and cardiac muscle.
C) H3 receptor on presynaptic nerves in CNS.
D) All the above may apply.
10. Which of the following actions is not mediated by Histamine:
A) Dilatation of blood capillaries.
B) Increased permeability of blood capillaries
C) Tachycardia and extrasystoles
D) Bronchodilatation.
11. Histamine is a powerful stimulant for gastric acid secretion from parietal cells and mildly
potentiates pepsin and gastrin secretions via H2 receptor.
A) True.
B) False.
12. Which of the following actions is mediated by Histamine:
A) Hypotension.
B) Hyperacidity.
C) Paralytic ileus.
D) Both A and B may apply.
13. Betazole is a specific H2 receptor agonist and differs from histamine in that it can be given orally,
of slow onset, and of longer duration.
A) True.
B) False.
14. Triple response is mediated by intradermal injection of histamine or a sting which consists of
local red spot due to capillary dilatation; spreading flare due to arteriolar dilatation as a result of
axon reflex; and a wheel of edema due to increased capillary permeability.
A) True.
B) False.
Autacoid Pharmacology Surviving Revision
PHARMACOLOGY, AUTACOIDS (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
AUTACOIDS-1
MCQs
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
1. The term “Autacoid” means:
A) Naturally occurring substances.
B) Synthesized, released, and metabolized locally within a tissue.
C) Have variable pharmacological actions and usually vasoactive.
D) All the above.
2. Which of the following is considered an Autacoid:
A) 5-hydroxy-trytamine.
B) Prostaglandin E2.
C) Angiotensin.
D) All the above.
3. Which of the following features is associated with Histamine as an autacoid:
A) Synthesized from Histidine.
B) Synthesized from Tryptophan.
C) Betazole is a synthetic analogue.
D) Both A & C may apply.
4. Histamine:
A) Synthesized by Histidine decarboxylase.
B) Stored in specialized intracellular granules in mast cells.
C) Mainly occurs as bound form together with heparin and protein.
D) All the above.
5. Histamine could be released by:
A) Proteolytic enzymes as trypsin in venoms and toxins.
B) Drugs which can displace histamine from tissues as morphine.
C) Antigens or allergens via immunological reaction on mast cell membrane.
D) All the above.
6. Which of the following drugs are associated with Histamine release:
A) Basic drugs as d-tubocurarine.
B) Acidic drugs as aspirin.
C) Both of them.
D) None of them.
Autacoid Pharmacology Surviving Revision
, BENHA UNIVERSITY, CREDIT HOURS SYSTEM
7. Labile or free form of Histamine occurs in little amounts could be released by histamine
liberators.
A) True.
B) False.
8. Which of the following statements is true regarding Histamine?
A) A biologic amine with a histaminopexic power.
B) Ineffective orally.
C) Cannot pass blood-brain barrier.
D) All the above may apply.
9. Which of the following receptors could be activated by Histamine?
A) H1 receptor on smooth muscles and sensory nerve endings.
B) H2 receptor on gastric glands and cardiac muscle.
C) H3 receptor on presynaptic nerves in CNS.
D) All the above may apply.
10. Which of the following actions is not mediated by Histamine:
A) Dilatation of blood capillaries.
B) Increased permeability of blood capillaries
C) Tachycardia and extrasystoles
D) Bronchodilatation.
11. Histamine is a powerful stimulant for gastric acid secretion from parietal cells and mildly
potentiates pepsin and gastrin secretions via H2 receptor.
A) True.
B) False.
12. Which of the following actions is mediated by Histamine:
A) Hypotension.
B) Hyperacidity.
C) Paralytic ileus.
D) Both A and B may apply.
13. Betazole is a specific H2 receptor agonist and differs from histamine in that it can be given orally,
of slow onset, and of longer duration.
A) True.
B) False.
14. Triple response is mediated by intradermal injection of histamine or a sting which consists of
local red spot due to capillary dilatation; spreading flare due to arteriolar dilatation as a result of
axon reflex; and a wheel of edema due to increased capillary permeability.
A) True.
B) False.
Autacoid Pharmacology Surviving Revision
