BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, REPRODUCTIVE SYSTEM (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
REPRODUCTIVE DRUGS (Quiz + Answers)
Notes:
(i) Read the associated signs and diagnose the case.
(ii) Answer the questions after carefully reading the text.
Which of the following has a tocolytic effect (could suppress the initiating labour)?
A) Administration of an antagonist of the actions of progesterone
B) Administration of luteinizing hormone
C) Administration of an antagonist of prostaglandin E2 effects
D) Administration of oxytocin
The answer is (C).
The condition of premature labour may result in death of the neonate.
PGE2 strongly stimulates uterine smooth muscle contraction and is synthesized in
an increasing manner by the placenta late in gestation. Therefore, administration
of a safe anti-prostaglandin agent as glucocorticoids may be beneficial.
Progesterone is the main hormone that maintains pregnancy; therefore, its
antagonism will increase uterine contractility.
LH would have no effect.
Oxytocin also will increase uterine smooth muscle contraction.
Spermatogenesis is initiated by FSH and controlled by a negative feedback mechanism.
What is the limiting feedback messenger that inhibits pituitary formation of FSH?
A) Inhibin
B) Estrogen
C) Testosterone
D) Luteinizing hormone
The answer is (A).
Sertoli cells of the seminiferous tubules secrete inhibin at a rate proportional
to the rate of production of sperm cells. Inhibin has a direct inhibitory effect
on anterior pituitary secretion of FSH.
Reproductive system Pharmacology Surviving Revision
PHARMACOLOGY, REPRODUCTIVE SYSTEM (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
REPRODUCTIVE DRUGS (Quiz + Answers)
Notes:
(i) Read the associated signs and diagnose the case.
(ii) Answer the questions after carefully reading the text.
Which of the following has a tocolytic effect (could suppress the initiating labour)?
A) Administration of an antagonist of the actions of progesterone
B) Administration of luteinizing hormone
C) Administration of an antagonist of prostaglandin E2 effects
D) Administration of oxytocin
The answer is (C).
The condition of premature labour may result in death of the neonate.
PGE2 strongly stimulates uterine smooth muscle contraction and is synthesized in
an increasing manner by the placenta late in gestation. Therefore, administration
of a safe anti-prostaglandin agent as glucocorticoids may be beneficial.
Progesterone is the main hormone that maintains pregnancy; therefore, its
antagonism will increase uterine contractility.
LH would have no effect.
Oxytocin also will increase uterine smooth muscle contraction.
Spermatogenesis is initiated by FSH and controlled by a negative feedback mechanism.
What is the limiting feedback messenger that inhibits pituitary formation of FSH?
A) Inhibin
B) Estrogen
C) Testosterone
D) Luteinizing hormone
The answer is (A).
Sertoli cells of the seminiferous tubules secrete inhibin at a rate proportional
to the rate of production of sperm cells. Inhibin has a direct inhibitory effect
on anterior pituitary secretion of FSH.
Reproductive system Pharmacology Surviving Revision
