BREAST
SUMMARY OF
INDEX
BREAST CARCINOMA
BENIGN TUMORS OF THE BREAST
FIBRO-CYSTIC DISEASE
ACUTE LACTATIONAL MASTITIS
MAMMARY DUCT ECTASIA
if you found it useful
kindly share!
, RARE TYPES:
• PAGET'S DS.
• INFLAM. CARCINOMA.
ETIOLOGY PATH.
“LARGE – INTERMEDIATE” “TERMINAL – ACINI”
GENETIC UN-OPPOSED (E) HIGH RISK DUCTAL LOBULAR
(80%) (10 -15%)
MUTATION IN TUMOR 1) Early menarche. 1) hx. of cancer in
SUPPRESSOR GENE 1breast or +ve FH. NON-INVASIVE NON-INVASIVE
2) late menopause. INVASIVE
(DCIS) (LCIS)
1) BRCA1 on Ch. 17. 3) Null para / non- 2) Pre-malig.: Fibro-
2) BRCA2 on Ch. 13. lactating. adenosis e papillomatosis. · NOS
& Atypical deuctal Turns to Invasive
3) TP53 on Ch. 17. 4) OCPs > 10 ys. · Medullary.
hyperplasia. after 2ys. · Bilateral - multi-centeric. ®
5) Obesity & White race. · Mucinous. # of Conserv. Breast surgery.
· Discovered acc. on biopsy.
· No m calcifications.
NOS MEDULLARY “ENCEPHALOID” MUCINOUS (COLLOID)
· Turns to Invasive Ductal
% 75% 5% 1% Carcinoma ig. after 15 ys.
NE Small, irregular & Hard. Large, irregular & Soft. “Brain like” Large & cystic.
CS · Extensive fibrous t. ® Gritty. · Highly cellular ® Soft. Honey comb app.
· Concave. “retract” · Convex. “bulgined”
· Non-capsulated + HNC. · Non-capsulated + HNC.
MICRO · Malig. spheroidal cells · Malig. spheroidal cells. · Malig. cells.
· irreg. arranged. · pseudo-acinus -no fibrous tissue · producing mucin ®
· highly vascular + lymphocytic infilt. Signet ring app.
1
PROG. Bad Good Good unlike the GIT
SUMMARY OF
INDEX
BREAST CARCINOMA
BENIGN TUMORS OF THE BREAST
FIBRO-CYSTIC DISEASE
ACUTE LACTATIONAL MASTITIS
MAMMARY DUCT ECTASIA
if you found it useful
kindly share!
, RARE TYPES:
• PAGET'S DS.
• INFLAM. CARCINOMA.
ETIOLOGY PATH.
“LARGE – INTERMEDIATE” “TERMINAL – ACINI”
GENETIC UN-OPPOSED (E) HIGH RISK DUCTAL LOBULAR
(80%) (10 -15%)
MUTATION IN TUMOR 1) Early menarche. 1) hx. of cancer in
SUPPRESSOR GENE 1breast or +ve FH. NON-INVASIVE NON-INVASIVE
2) late menopause. INVASIVE
(DCIS) (LCIS)
1) BRCA1 on Ch. 17. 3) Null para / non- 2) Pre-malig.: Fibro-
2) BRCA2 on Ch. 13. lactating. adenosis e papillomatosis. · NOS
& Atypical deuctal Turns to Invasive
3) TP53 on Ch. 17. 4) OCPs > 10 ys. · Medullary.
hyperplasia. after 2ys. · Bilateral - multi-centeric. ®
5) Obesity & White race. · Mucinous. # of Conserv. Breast surgery.
· Discovered acc. on biopsy.
· No m calcifications.
NOS MEDULLARY “ENCEPHALOID” MUCINOUS (COLLOID)
· Turns to Invasive Ductal
% 75% 5% 1% Carcinoma ig. after 15 ys.
NE Small, irregular & Hard. Large, irregular & Soft. “Brain like” Large & cystic.
CS · Extensive fibrous t. ® Gritty. · Highly cellular ® Soft. Honey comb app.
· Concave. “retract” · Convex. “bulgined”
· Non-capsulated + HNC. · Non-capsulated + HNC.
MICRO · Malig. spheroidal cells · Malig. spheroidal cells. · Malig. cells.
· irreg. arranged. · pseudo-acinus -no fibrous tissue · producing mucin ®
· highly vascular + lymphocytic infilt. Signet ring app.
1
PROG. Bad Good Good unlike the GIT
