TESTIS
SUMMARY OF
INDEX
TESTICULAR NEOPLASM
TESTICULAR CYSTS
EPIDIDYMO-ORCHITIS
TORSION TESTIS
UNDESCENDED TESTIS
VARICOCELE
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, 99% of testicular tumors are malig. / Bilat. in 3-5%
Etiology
GERM CELL TUMORS INTERSTITIAL TUMORS
2RY TUMORS
1) Incomp. descended tetsis (85%) (1.5%)
esp. intra-abdominal.
1) Leydig Cell tumor.
2) Klinefelter's $. 1) Seminoma. 40% · Lymphoma. 7%
2) Sertoli cell tumor:
3) Iso-chromosome 12p. 2) Teratoma. (Non- seminoma) 32% · Leukimic infilt.
· After puberty.
(80% of testicular tumors) 3) Combined. 14% · Metastatic.
· Bening - feminize.
SEMINOMA (40%) TERATOMA (32%)
AGE 35 – 45 ys. 20 – 35 ys.
CELL OF ORIGIN Spermatocytes in the Seminiferous tubules. Embryonic (Totipotent) cells in the rete testis.
MAC. · Size ® Moderate to large. · Size ® Variable (small as a peanut large as coconut)
· Surface ® Smooth – lobulated. · Surface ® Smooth.
· C/S ® homog. & pink creamy in color. · C/S ® heterog. & Yellow containing gelat. mat. & cartilage.
MIC. 1) Sheets of Rounded or oval cells resemble Spermatocytes: 1) Dermoid cyst. (Malig. Teratoma Differentiated)
· Rounded or oval cells. 2) Terato-Carcinoma (M/C). (Malig. Teratoma Intermediate)
· Vacuolated cytoplasm. 3) Emberyonal carcinoma. (Malig. Teratoma Anaplastica)
2) Lymphocytic infiltration. 4) Choriocarcinoma. (M/D) (Malig. Teratoma Trophoblastica)
LDH: 5) Endodermal Sinus Tumor. “EST”
SPREAD (MAINLY) · Leukemia.
Lymphatics to the para-aortic & iliac LNs. Blood mainly to lungs.
· Lymphoma.
TUMOR MARKERS 1) b-HCG in 10%. · Seminoma. 1) b-HCG in 100% of Chorio-carcinoma.
(SEE INVEST.) 2) LDH. · Pulm. Embolism
2) a -FP in 75%.
TTT. & STAGING · high Retro-grade inguinal Orchiectomy in both! · Postop. Chemotherapy. (highly radio-resistant)
1
· Post-op. Radioth. for LNs & Cisplatin for dx. metastasis. · Retro-peritoneal Lymphadenectomy after chemo th.
SUMMARY OF
INDEX
TESTICULAR NEOPLASM
TESTICULAR CYSTS
EPIDIDYMO-ORCHITIS
TORSION TESTIS
UNDESCENDED TESTIS
VARICOCELE
if you found it useful
kindly share!
, 99% of testicular tumors are malig. / Bilat. in 3-5%
Etiology
GERM CELL TUMORS INTERSTITIAL TUMORS
2RY TUMORS
1) Incomp. descended tetsis (85%) (1.5%)
esp. intra-abdominal.
1) Leydig Cell tumor.
2) Klinefelter's $. 1) Seminoma. 40% · Lymphoma. 7%
2) Sertoli cell tumor:
3) Iso-chromosome 12p. 2) Teratoma. (Non- seminoma) 32% · Leukimic infilt.
· After puberty.
(80% of testicular tumors) 3) Combined. 14% · Metastatic.
· Bening - feminize.
SEMINOMA (40%) TERATOMA (32%)
AGE 35 – 45 ys. 20 – 35 ys.
CELL OF ORIGIN Spermatocytes in the Seminiferous tubules. Embryonic (Totipotent) cells in the rete testis.
MAC. · Size ® Moderate to large. · Size ® Variable (small as a peanut large as coconut)
· Surface ® Smooth – lobulated. · Surface ® Smooth.
· C/S ® homog. & pink creamy in color. · C/S ® heterog. & Yellow containing gelat. mat. & cartilage.
MIC. 1) Sheets of Rounded or oval cells resemble Spermatocytes: 1) Dermoid cyst. (Malig. Teratoma Differentiated)
· Rounded or oval cells. 2) Terato-Carcinoma (M/C). (Malig. Teratoma Intermediate)
· Vacuolated cytoplasm. 3) Emberyonal carcinoma. (Malig. Teratoma Anaplastica)
2) Lymphocytic infiltration. 4) Choriocarcinoma. (M/D) (Malig. Teratoma Trophoblastica)
LDH: 5) Endodermal Sinus Tumor. “EST”
SPREAD (MAINLY) · Leukemia.
Lymphatics to the para-aortic & iliac LNs. Blood mainly to lungs.
· Lymphoma.
TUMOR MARKERS 1) b-HCG in 10%. · Seminoma. 1) b-HCG in 100% of Chorio-carcinoma.
(SEE INVEST.) 2) LDH. · Pulm. Embolism
2) a -FP in 75%.
TTT. & STAGING · high Retro-grade inguinal Orchiectomy in both! · Postop. Chemotherapy. (highly radio-resistant)
1
· Post-op. Radioth. for LNs & Cisplatin for dx. metastasis. · Retro-peritoneal Lymphadenectomy after chemo th.
