BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
Problem Figure Questions
Notes:
i. Please look at the following D-R CURVES. Then mark the appended statements as ( √ ) or ( × ).
ii. Answer the questions after carefully reading the text.
100%
(A) (B) (A+C)
Response (%)
50% (B+D)
(E)
ED50 (A) ED50 (B)
Dose (Log)
1- Drugs A and B have the same intrinsic activities. (√)
2- Drug B is more efficacious than drug A. (×)
3- Drug E is less efficacious than drug B. (√)
4- Drug D is a competitive antagonist to drug B. (×)
5- Drug C is a competitive antagonist to drug A. (√)
6- Regarding potency: A = B > E. (×)
7- Regarding efficacy: A = B > E. (√)
8- ED50 of drug A is < ED50 of drug B. (√)
9- If drug A is acetylcholine, the drug C can be exemplified by organophosphates. (×)
10- If drug B is acetylcholine, the drug D can be exemplified by succinylcholine. (√)
[End of questions; Total points = 20]
General Pharmacology Surviving Revision
,BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
MCQs with ANSWERS
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
Q1 A general term describing the actions of the drugs on the body:
A Pharmacodynamics
B Pharmacogenetics
C Pharmacokinetics
D Pharmacotherapeutics
Q2 Posology is a branch of pharmacology that deals with the study of:
A actions and mechanisms of actions of drugs
B absorption and distribution of drugs
C metabolism and excretion of drugs
D dose and dosage of drugs
Q3 The mechanism of action of mannitol as diuretic is an example for:
A adsorption
B osmosis
C chelation
D replacement
Q4 An antagonist has the following properties, except:
A Affinity
B Efficacy
C High Ka
D Low Kd
Q5 Effects of histamine & adrenaline on bronchi is an example for:
A Physiological antagonism
B Chemical antagonism
C Competitive antagonism
D Noncompetitive antagonism
Q6 Prolongation of procaine duration of action by adrenaline is an example for:
A potentiation
B summation
C synergism
D antagonism
Q7 To be absorbed from the skin, a drug should be incorporated in:
A lanoline base
B vaseline base
C polyoxyethylene base
D A or C may apply
Q8 First pass effect is the main disadvantage of ………… route of administration:
A intravenous
B oral
C subcutaneous
D intramuscular
General Pharmacology Surviving Revision
,BENHA UNIVERSITY, CREDIT HOURS SYSTEM
TFQs with ANSWERS
Each of the next questions consists of TWO statements; judge if they are True or False & then choose:
Ⓐ If the FIRST statement ONLY is TRUE
Ⓑ If the SECOND statement ONLY is TRUE
Ⓒ If BOTH statements are TRUE
Ⓓ If BOTH statements are FALSE
# 1st sentence 2nd sentence Ans.
Q1 Therapeutic index is calculated as LD1/ED50 × it is a measure of drug safety √ B
Q2 Insulin acts via specific receptor √ Insulin receptor is coupled to Gp × A
Q3 Primaquine is an antibacterial drug × It is prohibited in patients deficient in G-6-PD √ B
To be absorbed, a drug may move against its This pathway is named “Active transport” of
Q4 C
concentration gradient across cell membranes √ drugs √
Q5 Tetracycline is a bactericidal drug × It tends to accumulate in bones & teeth √ B
Alkalinization of urine could be achieved by This increases excretion of weak acid drugs as
Q6 C
NaHCO3 √ aspirin √
Sulphonamides are an example for synthetic Their mechanism of action is an example for
Q7 C
antibacterial drugs √ substrate antagonism √
Streptomycin is useful in case of pneumonia Its best therapeutic effect can be achieved via its
Q8 A
caused by Gram-negative bacteria √ oral route administration ×
Rabbits can tolerate larger doses of atropine than This type of tolerance is called “Acquired
Q9 A
other species √ tolerance” ×
Affinity means tendency and ability of a drug to
Q10 An agonist has the property of high affinity √ C
combine with a specific receptor √
Q11 An antagonist has high Kd × Kd means “Ionization constant” × D
Benzathine-penicillin is among long-acting
Q12 It is given at time intervals of 3-4 weeks √ C
penicillins √
Passive diffusion of a drug across cell membranes
Q13 It does not need a carrier and/or ATP √ B
occurs against concentration gradient ×
Physostigmine (Mol. Wt < 500) is a lipid-soluble So, it follows multicompartment pattern
Q14 C
drug √ distribution √
Drugs having Amino/Alkyl groups are mainly Oxidation reactions are belonging to Phase-2
Q15 A
metabolized by oxidation √ biotransformation reactions ×
Atropine & Acetylcholine compete The type of antagonism between Atropine &
Q16 D
pharmacologically for N-receptors × Acetylcholine is non-competitive ×
Suppositories are drug forms intended to be Suppositories are drug forms intended to be
Q17 B
administered via vaginal route × administered via rectal route √
Irritant drugs can be given via intravenous route Irritant drugs can be given via intraperitoneal
Q18 A
of administration √ route of administration ×
Facilitated diffusion occurs against concentration
Q19 It does not a carrier or ATP × D
gradient of a drug ×
The common site of intravenous administration The common site of intravenous administration
Q20 C
in dogs is the recurrent tarsal vein √ in human is the cubital vein √
Tolerance may occur after repeated This type of tolerance is named “Congenital
Q21 A
administration of barbitone √ tolerance” ×
Synergism means decreased response upon co- Co-administration of chloralhydrate and a
Q22 B
administration of two drugs × barbiturate is an example √
[End of questions; Total points = 30]
General Pharmacology Surviving Revision
, BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
MCQs
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
1- If the oral dose is considered as the unit; then the SC dose should be:
a. Twice as the oral dose
b. 1/4 of the oral dose
c. 1/3 of the oral dose
d. 1/2 of the oral dose
2- Antagonism between acetylcholine and organophosphates is an example for:
a. Chemical antagonism
b. Competitive antagonism
c. Non-competitive reversible antagonism
d. Non-competitive irreversible antagonism
3- The most suitable route of administration of irritant drugs is:
a. IP route
b. SC route
c. IM route
d. IV route
4- Benzathine penicillin is given every:
a. 4 hours
b. 12 hours
c. 24 hours
d. One month
5- Therapeutic index is calculated as:
a. ED50 / LD50
b. LD50 / ED50
c. ED99 / LD1
d. LD1 / ED99
6- Degree of ionization of a drug can be determined by:
a. Clark's formula
b. Dilling's formula
c. Henderson-Hasselbalch's equation
d. None of the above
General Pharmacology Surviving Revision
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
Problem Figure Questions
Notes:
i. Please look at the following D-R CURVES. Then mark the appended statements as ( √ ) or ( × ).
ii. Answer the questions after carefully reading the text.
100%
(A) (B) (A+C)
Response (%)
50% (B+D)
(E)
ED50 (A) ED50 (B)
Dose (Log)
1- Drugs A and B have the same intrinsic activities. (√)
2- Drug B is more efficacious than drug A. (×)
3- Drug E is less efficacious than drug B. (√)
4- Drug D is a competitive antagonist to drug B. (×)
5- Drug C is a competitive antagonist to drug A. (√)
6- Regarding potency: A = B > E. (×)
7- Regarding efficacy: A = B > E. (√)
8- ED50 of drug A is < ED50 of drug B. (√)
9- If drug A is acetylcholine, the drug C can be exemplified by organophosphates. (×)
10- If drug B is acetylcholine, the drug D can be exemplified by succinylcholine. (√)
[End of questions; Total points = 20]
General Pharmacology Surviving Revision
,BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
MCQs with ANSWERS
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
Q1 A general term describing the actions of the drugs on the body:
A Pharmacodynamics
B Pharmacogenetics
C Pharmacokinetics
D Pharmacotherapeutics
Q2 Posology is a branch of pharmacology that deals with the study of:
A actions and mechanisms of actions of drugs
B absorption and distribution of drugs
C metabolism and excretion of drugs
D dose and dosage of drugs
Q3 The mechanism of action of mannitol as diuretic is an example for:
A adsorption
B osmosis
C chelation
D replacement
Q4 An antagonist has the following properties, except:
A Affinity
B Efficacy
C High Ka
D Low Kd
Q5 Effects of histamine & adrenaline on bronchi is an example for:
A Physiological antagonism
B Chemical antagonism
C Competitive antagonism
D Noncompetitive antagonism
Q6 Prolongation of procaine duration of action by adrenaline is an example for:
A potentiation
B summation
C synergism
D antagonism
Q7 To be absorbed from the skin, a drug should be incorporated in:
A lanoline base
B vaseline base
C polyoxyethylene base
D A or C may apply
Q8 First pass effect is the main disadvantage of ………… route of administration:
A intravenous
B oral
C subcutaneous
D intramuscular
General Pharmacology Surviving Revision
,BENHA UNIVERSITY, CREDIT HOURS SYSTEM
TFQs with ANSWERS
Each of the next questions consists of TWO statements; judge if they are True or False & then choose:
Ⓐ If the FIRST statement ONLY is TRUE
Ⓑ If the SECOND statement ONLY is TRUE
Ⓒ If BOTH statements are TRUE
Ⓓ If BOTH statements are FALSE
# 1st sentence 2nd sentence Ans.
Q1 Therapeutic index is calculated as LD1/ED50 × it is a measure of drug safety √ B
Q2 Insulin acts via specific receptor √ Insulin receptor is coupled to Gp × A
Q3 Primaquine is an antibacterial drug × It is prohibited in patients deficient in G-6-PD √ B
To be absorbed, a drug may move against its This pathway is named “Active transport” of
Q4 C
concentration gradient across cell membranes √ drugs √
Q5 Tetracycline is a bactericidal drug × It tends to accumulate in bones & teeth √ B
Alkalinization of urine could be achieved by This increases excretion of weak acid drugs as
Q6 C
NaHCO3 √ aspirin √
Sulphonamides are an example for synthetic Their mechanism of action is an example for
Q7 C
antibacterial drugs √ substrate antagonism √
Streptomycin is useful in case of pneumonia Its best therapeutic effect can be achieved via its
Q8 A
caused by Gram-negative bacteria √ oral route administration ×
Rabbits can tolerate larger doses of atropine than This type of tolerance is called “Acquired
Q9 A
other species √ tolerance” ×
Affinity means tendency and ability of a drug to
Q10 An agonist has the property of high affinity √ C
combine with a specific receptor √
Q11 An antagonist has high Kd × Kd means “Ionization constant” × D
Benzathine-penicillin is among long-acting
Q12 It is given at time intervals of 3-4 weeks √ C
penicillins √
Passive diffusion of a drug across cell membranes
Q13 It does not need a carrier and/or ATP √ B
occurs against concentration gradient ×
Physostigmine (Mol. Wt < 500) is a lipid-soluble So, it follows multicompartment pattern
Q14 C
drug √ distribution √
Drugs having Amino/Alkyl groups are mainly Oxidation reactions are belonging to Phase-2
Q15 A
metabolized by oxidation √ biotransformation reactions ×
Atropine & Acetylcholine compete The type of antagonism between Atropine &
Q16 D
pharmacologically for N-receptors × Acetylcholine is non-competitive ×
Suppositories are drug forms intended to be Suppositories are drug forms intended to be
Q17 B
administered via vaginal route × administered via rectal route √
Irritant drugs can be given via intravenous route Irritant drugs can be given via intraperitoneal
Q18 A
of administration √ route of administration ×
Facilitated diffusion occurs against concentration
Q19 It does not a carrier or ATP × D
gradient of a drug ×
The common site of intravenous administration The common site of intravenous administration
Q20 C
in dogs is the recurrent tarsal vein √ in human is the cubital vein √
Tolerance may occur after repeated This type of tolerance is named “Congenital
Q21 A
administration of barbitone √ tolerance” ×
Synergism means decreased response upon co- Co-administration of chloralhydrate and a
Q22 B
administration of two drugs × barbiturate is an example √
[End of questions; Total points = 30]
General Pharmacology Surviving Revision
, BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, GENERAL (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
MCQs
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
1- If the oral dose is considered as the unit; then the SC dose should be:
a. Twice as the oral dose
b. 1/4 of the oral dose
c. 1/3 of the oral dose
d. 1/2 of the oral dose
2- Antagonism between acetylcholine and organophosphates is an example for:
a. Chemical antagonism
b. Competitive antagonism
c. Non-competitive reversible antagonism
d. Non-competitive irreversible antagonism
3- The most suitable route of administration of irritant drugs is:
a. IP route
b. SC route
c. IM route
d. IV route
4- Benzathine penicillin is given every:
a. 4 hours
b. 12 hours
c. 24 hours
d. One month
5- Therapeutic index is calculated as:
a. ED50 / LD50
b. LD50 / ED50
c. ED99 / LD1
d. LD1 / ED99
6- Degree of ionization of a drug can be determined by:
a. Clark's formula
b. Dilling's formula
c. Henderson-Hasselbalch's equation
d. None of the above
General Pharmacology Surviving Revision
