Pharmacology- Antidiarrheal Quiz Questions and Answers
2024/2025 Solved 100%
Antidiarrheal agents may be used in mild to moderate acute diarrhea or chronic
diarrhea but should NOT be used in patients with ____
Bloody diarrhea, high fever, or systemic toxicity
____ is a nonprescription opioid agonist that does not cross the BBB and
tolerance has not been reported
Loperamide
_____ is a prescription opioid agonist which at high doses can have CNS effects
Diphenoxylate
Conjugated bile salts are normally absorbed in the _____
Terminal ileum
What are the 3 bile salt-binding resins that may decrease diarrhea caused by
excess fecal bile acids?
Cholestyramine, colestipol, or colesevelam
Which of the bile-salt binding resins should NOT be given within 2 hours of other
drugs due to reduced absorption?
Cholestyramine and Colestipol
______ is a 14-amino-acid peptide that is released in the GI and pancreas
Somatostatin
Somatostatin has many effects that are honestly not worth your time to memorize
for the quiz
Inhibits secretion of numerous hormones and transmitters, reduces intestinal
fluid/pancreatic secretion, reduces portal and splanchnic blood flow, and slows GI
motility and inhibits gallbladder contraction
T/F: The clinical usefulness of somatostatin is limited by its short half-life in the
circulation when administered IV
True
_____ is a synthetic octapeptide with actions similar to somatostatin
Octreotide
Octreotide inhibits the effects of which 2 GI neuroendocrine tumors that cause
secretory diarrhea and systematic symptoms such as flushing and wheezing?
Carcinoid and VIPoma
T/F: At low doses octreotide stimulates motility and at high doses it inhibits
motility
True
Because of inhibition of gallbladder contractility and alterations in fat absorption,
long-term use of octreotide can cause formation of _____ or _____ in over 50% of
patients
Sludge or gallstones
Because octreotide inhibits pancreatic secretion it may cause steatorrhea which
can lead to a ______ deficiency
Fat-soluble vitamin (ADEK)
Prolonged treatment with octreotide may result in _____
2024/2025 Solved 100%
Antidiarrheal agents may be used in mild to moderate acute diarrhea or chronic
diarrhea but should NOT be used in patients with ____
Bloody diarrhea, high fever, or systemic toxicity
____ is a nonprescription opioid agonist that does not cross the BBB and
tolerance has not been reported
Loperamide
_____ is a prescription opioid agonist which at high doses can have CNS effects
Diphenoxylate
Conjugated bile salts are normally absorbed in the _____
Terminal ileum
What are the 3 bile salt-binding resins that may decrease diarrhea caused by
excess fecal bile acids?
Cholestyramine, colestipol, or colesevelam
Which of the bile-salt binding resins should NOT be given within 2 hours of other
drugs due to reduced absorption?
Cholestyramine and Colestipol
______ is a 14-amino-acid peptide that is released in the GI and pancreas
Somatostatin
Somatostatin has many effects that are honestly not worth your time to memorize
for the quiz
Inhibits secretion of numerous hormones and transmitters, reduces intestinal
fluid/pancreatic secretion, reduces portal and splanchnic blood flow, and slows GI
motility and inhibits gallbladder contraction
T/F: The clinical usefulness of somatostatin is limited by its short half-life in the
circulation when administered IV
True
_____ is a synthetic octapeptide with actions similar to somatostatin
Octreotide
Octreotide inhibits the effects of which 2 GI neuroendocrine tumors that cause
secretory diarrhea and systematic symptoms such as flushing and wheezing?
Carcinoid and VIPoma
T/F: At low doses octreotide stimulates motility and at high doses it inhibits
motility
True
Because of inhibition of gallbladder contractility and alterations in fat absorption,
long-term use of octreotide can cause formation of _____ or _____ in over 50% of
patients
Sludge or gallstones
Because octreotide inhibits pancreatic secretion it may cause steatorrhea which
can lead to a ______ deficiency
Fat-soluble vitamin (ADEK)
Prolonged treatment with octreotide may result in _____
