Gestational Trophoblastic
Disease (Hydatidiform mole)
Description
1. Hydatidiform mole is an alteration of early embryonic growth causing
placental disruption, rapid proliferation of abnormal cells, and
destruction of the embryo.
2. There are two distinct types of hydatidiform moles-complete and partial.
▪ In a complete mole, the chromosomes are either 46XX or 46XY but
are contributed by only one parent and the chromosome material
duplicated. This type usually leads to choriocarcinoma.
▪ A partial mole has 69 chromosomes. There are three chromosomes
for every pair instead of two. This type of mole rarely leads to
choriocarcinoma.
Aetiology
▪ The aetiology of hydatidiform moles is unknown. Genetic, ovular, or
nutritional abnormalities could possibility be responsible for
trophoblastic disease.
Pathophysiology
1. A hydatidiform mole is a placental tumour that develops after
pregnancy has occurred; it may be benign or malignant. The risk of
malignancy is greater with a complete mole.
Disease (Hydatidiform mole)
Description
1. Hydatidiform mole is an alteration of early embryonic growth causing
placental disruption, rapid proliferation of abnormal cells, and
destruction of the embryo.
2. There are two distinct types of hydatidiform moles-complete and partial.
▪ In a complete mole, the chromosomes are either 46XX or 46XY but
are contributed by only one parent and the chromosome material
duplicated. This type usually leads to choriocarcinoma.
▪ A partial mole has 69 chromosomes. There are three chromosomes
for every pair instead of two. This type of mole rarely leads to
choriocarcinoma.
Aetiology
▪ The aetiology of hydatidiform moles is unknown. Genetic, ovular, or
nutritional abnormalities could possibility be responsible for
trophoblastic disease.
Pathophysiology
1. A hydatidiform mole is a placental tumour that develops after
pregnancy has occurred; it may be benign or malignant. The risk of
malignancy is greater with a complete mole.
