,ONCOGENS
, Cancer arises due to changes in the most important regulatory genes
that control cell proliferation, differentiation and survival. Studies of
tumor viruses have shown that certain genes(oncogenes)can lead to
cell transformation and thus provided the first insight into the
molecular basis of cancer. However, the majority(about 80%)of
cancer cases in humans is not caused by viruses and appears to be
due to other reasons, such as radiation and chemical
carcinogens.And.
A key link connecting viral and cellular oncogenes was discovered by
research on highly oncogenic retroviruses. Proto-oncogenes normally
encode numerous growth factors, tyrosine kinases, serine/threonine kinases,
receptors for growth factors, etc. These genes are normally present in the
cell, but if there are changes in these genes, they can be activated and are
then called oncogenes. Oncogenes can be defined as overexpressed or
mutated proto-oncogenes, which lead to uncontrolled cell proliferation and
cancer formation.
, Cancer arises due to changes in the most important regulatory genes
that control cell proliferation, differentiation and survival. Studies of
tumor viruses have shown that certain genes(oncogenes)can lead to
cell transformation and thus provided the first insight into the
molecular basis of cancer. However, the majority(about 80%)of
cancer cases in humans is not caused by viruses and appears to be
due to other reasons, such as radiation and chemical
carcinogens.And.
A key link connecting viral and cellular oncogenes was discovered by
research on highly oncogenic retroviruses. Proto-oncogenes normally
encode numerous growth factors, tyrosine kinases, serine/threonine kinases,
receptors for growth factors, etc. These genes are normally present in the
cell, but if there are changes in these genes, they can be activated and are
then called oncogenes. Oncogenes can be defined as overexpressed or
mutated proto-oncogenes, which lead to uncontrolled cell proliferation and
cancer formation.
