NBME CBSE REAL EXAM
QUESTIONS AND
ANSWERS LATEST
MEDICAL EXAMINATION
Which antidepressant requires wash-out - answer is MAOI
(Phenelzine, selegiline)
What is serotonin made from - answer is tryptophan
TCA - answer is Amitriptyline
inhibit *fast Na* channels
dose limiting AE from amitriptyline - answer is arrhythmia
tx: sodium bicarb
TCA OD treatment - answer is sodium bicarb
OD = seizure, hypotension, prolonged QRS
TCA AE due to blocking - answer is mAChR
a1
NE/5HT reuptake
H1-R
--> confusion, constipation, urinary retention
,Olanzapine, Clozapine - answer is 2nd gen antipsych + MOOD
AE of Olanzapine, Clozapine - answer is metabolic syndrome (wt
gain)
(atypical antipsychotic)
Trazodone - answer is MDD + Insomnia
Trazodone AE - answer is priapism
Ramelteon - answer is Melatonin Agonist (*for elderly)
Sleep aid for elderly - answer is Ramelteon
Atomoxetine - answer is tx ADHD
nonstimulant
*NE reuptake inhibitor*
Haloperidol - answer is 1st gen antipsych
tx delerium
Donepezil - answer is cholesterase inhibitor
tx: dementia
Benzo MOA - answer is allosterically bind GABA to
increase Cl frequency of opening
Lorazepam IV - answer is status epilepticus
Phenytoin - answer is Na block
,PREVENT seizure recurrence
What should you not combine with a benzo - answer is 1st gen
antihistamine
(Chlorpheniramine)
--> SEDATION TOO MUCH
Ethosuximide - answer is absence seizures
blocks thalamic* Ca T-type* channel
Lamotrigine - answer is Na channel block
tx: seizures + biploar
AE of lamotrigine - answer is SJS
(tx seizure/bipolar)
What is used for essential tremors - answer is propranolol
**pt reports improved symptoms w alcohol
Gabapentin - answer is inhibit pre-s voltage gated *Ca ch*
= inhibit fusion/*release* of NT
tx: seizures, VZV pain
Carbamazepine - answer is tx: trigeminal neuralgia
decrease Na current
AE of carbamazepine - answer is *BM suppression*
, SIADH (low Na)
(tx seizures)
Valproate treats - answer is seizure + bipolar
Lithium AE - answer is hypothyroid
Polyuria/dipsia (ADH antagonist in CD)
PCP - answer is NMDA antagonist
violent, nystagmus
Cocaine - answer is blocks NE/DA/5HT reuptake
= sympathetic stimulation
Opioids - answer is decrease Ca influx
increase K efflux
Opioid AE - answer is contract sphincter of Oddi
--> biliary colic (cramping)
Methadone - answer is *full mu agonist*
long *t1/2* to suppress CRAVINGS/WITHDRAWAL
Buprenorphine - answer is partial agonist
= decrease resp/deperss
CAN PRECIPITATE OPIOID WITHDRAWAL SYMPTOMS
Diphenolynate - answer is mu agonist for GI
- SLOWS motility
QUESTIONS AND
ANSWERS LATEST
MEDICAL EXAMINATION
Which antidepressant requires wash-out - answer is MAOI
(Phenelzine, selegiline)
What is serotonin made from - answer is tryptophan
TCA - answer is Amitriptyline
inhibit *fast Na* channels
dose limiting AE from amitriptyline - answer is arrhythmia
tx: sodium bicarb
TCA OD treatment - answer is sodium bicarb
OD = seizure, hypotension, prolonged QRS
TCA AE due to blocking - answer is mAChR
a1
NE/5HT reuptake
H1-R
--> confusion, constipation, urinary retention
,Olanzapine, Clozapine - answer is 2nd gen antipsych + MOOD
AE of Olanzapine, Clozapine - answer is metabolic syndrome (wt
gain)
(atypical antipsychotic)
Trazodone - answer is MDD + Insomnia
Trazodone AE - answer is priapism
Ramelteon - answer is Melatonin Agonist (*for elderly)
Sleep aid for elderly - answer is Ramelteon
Atomoxetine - answer is tx ADHD
nonstimulant
*NE reuptake inhibitor*
Haloperidol - answer is 1st gen antipsych
tx delerium
Donepezil - answer is cholesterase inhibitor
tx: dementia
Benzo MOA - answer is allosterically bind GABA to
increase Cl frequency of opening
Lorazepam IV - answer is status epilepticus
Phenytoin - answer is Na block
,PREVENT seizure recurrence
What should you not combine with a benzo - answer is 1st gen
antihistamine
(Chlorpheniramine)
--> SEDATION TOO MUCH
Ethosuximide - answer is absence seizures
blocks thalamic* Ca T-type* channel
Lamotrigine - answer is Na channel block
tx: seizures + biploar
AE of lamotrigine - answer is SJS
(tx seizure/bipolar)
What is used for essential tremors - answer is propranolol
**pt reports improved symptoms w alcohol
Gabapentin - answer is inhibit pre-s voltage gated *Ca ch*
= inhibit fusion/*release* of NT
tx: seizures, VZV pain
Carbamazepine - answer is tx: trigeminal neuralgia
decrease Na current
AE of carbamazepine - answer is *BM suppression*
, SIADH (low Na)
(tx seizures)
Valproate treats - answer is seizure + bipolar
Lithium AE - answer is hypothyroid
Polyuria/dipsia (ADH antagonist in CD)
PCP - answer is NMDA antagonist
violent, nystagmus
Cocaine - answer is blocks NE/DA/5HT reuptake
= sympathetic stimulation
Opioids - answer is decrease Ca influx
increase K efflux
Opioid AE - answer is contract sphincter of Oddi
--> biliary colic (cramping)
Methadone - answer is *full mu agonist*
long *t1/2* to suppress CRAVINGS/WITHDRAWAL
Buprenorphine - answer is partial agonist
= decrease resp/deperss
CAN PRECIPITATE OPIOID WITHDRAWAL SYMPTOMS
Diphenolynate - answer is mu agonist for GI
- SLOWS motility
