acute leukemia

Acute Leukemia
Neoplastic proliferation of blasts
•


.




blasts
•


Defined as the accumulation
of > 20% in Bone


marrow .




Blast cells
•



usually enter the

blood stream ,
resulting in a



count
high KIBC .




immature cells
( Blasts large ,
.




often with punched out nucleus)



Acute leukemia is
classified in
•


:



(a) Acute
lymphoblastic leukemia ( ALL )

(b) Acute Leukemia (
myelogenous
AML )




Acute Lymphoblastic Leukemia
•
Acute lymphoblastic leukemia / lymphomas are
neoplasm
composed of immature B ( pre B) or T
( pre -
T ) cells ,




which are
referred as
lymphoblasts .




•


Neoplastic accumulation of lymphoblasts ( > 20%1 in


bone marrow .




Most children associated
commonly
• arises in with

Down Syndrome .