Immunopathology Unit
Department of Pathology
College of Medicine &
Medical City
King Saud University
, Reference
Kuby Immunology 8th Edition
Chapter 15
, Objectives
• To know that hypersensitivity reactions are over and excessive
immune responses that can be harmful to body in four different
ways
• To be familiar with inflammatory processes in Type I
hypersensitivity reaction that mediates allergic inflammation
• To recognize that Type II hypersensitivity deals with immune
responses against antigens that are integral part of cell membrane
and are usually associated with autoimmune disorders
• To know that Type III hypersensitivity reactions are mediated by
immune complexes and cause vasculitis
• To describe Type IV hypersensitivity is a purely cell mediated
immune response associated with chronic inflammation
, What is hypersensitivity?
• Protective immunity: desirable reaction
• Hypersensitivity: undesirable reaction
• Undesirable responses can be mediated by
– Antibody binding to antigens (Types I-III)
– Cell mediated reaction to chemicals or proteins
(Type IV)
Department of Pathology
College of Medicine &
Medical City
King Saud University
, Reference
Kuby Immunology 8th Edition
Chapter 15
, Objectives
• To know that hypersensitivity reactions are over and excessive
immune responses that can be harmful to body in four different
ways
• To be familiar with inflammatory processes in Type I
hypersensitivity reaction that mediates allergic inflammation
• To recognize that Type II hypersensitivity deals with immune
responses against antigens that are integral part of cell membrane
and are usually associated with autoimmune disorders
• To know that Type III hypersensitivity reactions are mediated by
immune complexes and cause vasculitis
• To describe Type IV hypersensitivity is a purely cell mediated
immune response associated with chronic inflammation
, What is hypersensitivity?
• Protective immunity: desirable reaction
• Hypersensitivity: undesirable reaction
• Undesirable responses can be mediated by
– Antibody binding to antigens (Types I-III)
– Cell mediated reaction to chemicals or proteins
(Type IV)