Walden NURS 6630 Psychopharmacology Study
Guide
classic synaptic neurotransmission
stimulation of a presynaptic neuron (e.g., by neurotransmitters, light, drugs, hormones,
nerve impulses) causes electrical impulses to be sent to its axon terminal. These
electrical impulses are then converted into chemical messengers and released to
stimulate the receptors of a postsynaptic neuron.
The synaptic cleft
is the gap between the presynaptic neuron and the postsynaptic neuron; it contains
proteins and scaffolding and molecular forms of "synaptic glue" to reinforce the
connection between the neurons. Receptors are present on both sides of this cleft and
are key elements of chemical neurotransmission.
the soma
is the command center of the nerve and contains the nucleus of the cell
axon
Neurons send information via an ____ that forms presynaptic terminals as the ____
passes by (en passant) or as the ____ ends
axodendritic
synaptic connections between the axon and dendrites of two neurons
axosomatic
synaptic connections between the axon and the soma
axoaxonic
synaptic connections between axons of the two neurons
The chemical basis of neurotransmission
is how chemical signals are coded, decoded, transduced, and sent along the way.
The anatomical basis of neurotransmission
is neurons and the connections between them, called synapses, sometimes also called
the anatomically addressed nervous system, a complex of "hard-wired" synaptic
connections between neurons, not unlike millions of telephone wires within thousands
upon thousands of cables
The cytochrome P450 (CYP) enzyme system
mediates how the body metabolizes many drugs, including antipsychotics.
The CYP enzyme
in the gut wall or liver converts the drug into a biotransformed product in the
bloodstream. After passing through the gut wall and liver, the drug will exist partly as
unchanged drug and partly as biotransformed drug.
agonist
produces a conformational change in the G-protein-linked receptor that turns on the
synthesis of second messenger to the greatest extent possible
full agonist
is generally represented by the naturally occurring neurotransmitter itself, although
some drugs can also act in as full a manner as the natural neurotransmitter
Constitutive activity
in the absence of agonist, the receptor's conformation is such that it leads to a low level
of activity
Guide
classic synaptic neurotransmission
stimulation of a presynaptic neuron (e.g., by neurotransmitters, light, drugs, hormones,
nerve impulses) causes electrical impulses to be sent to its axon terminal. These
electrical impulses are then converted into chemical messengers and released to
stimulate the receptors of a postsynaptic neuron.
The synaptic cleft
is the gap between the presynaptic neuron and the postsynaptic neuron; it contains
proteins and scaffolding and molecular forms of "synaptic glue" to reinforce the
connection between the neurons. Receptors are present on both sides of this cleft and
are key elements of chemical neurotransmission.
the soma
is the command center of the nerve and contains the nucleus of the cell
axon
Neurons send information via an ____ that forms presynaptic terminals as the ____
passes by (en passant) or as the ____ ends
axodendritic
synaptic connections between the axon and dendrites of two neurons
axosomatic
synaptic connections between the axon and the soma
axoaxonic
synaptic connections between axons of the two neurons
The chemical basis of neurotransmission
is how chemical signals are coded, decoded, transduced, and sent along the way.
The anatomical basis of neurotransmission
is neurons and the connections between them, called synapses, sometimes also called
the anatomically addressed nervous system, a complex of "hard-wired" synaptic
connections between neurons, not unlike millions of telephone wires within thousands
upon thousands of cables
The cytochrome P450 (CYP) enzyme system
mediates how the body metabolizes many drugs, including antipsychotics.
The CYP enzyme
in the gut wall or liver converts the drug into a biotransformed product in the
bloodstream. After passing through the gut wall and liver, the drug will exist partly as
unchanged drug and partly as biotransformed drug.
agonist
produces a conformational change in the G-protein-linked receptor that turns on the
synthesis of second messenger to the greatest extent possible
full agonist
is generally represented by the naturally occurring neurotransmitter itself, although
some drugs can also act in as full a manner as the natural neurotransmitter
Constitutive activity
in the absence of agonist, the receptor's conformation is such that it leads to a low level
of activity
