Nurs 6630 Exam 1: Chapter 47 STI Drugs (Answered)
Verified Solution
Syphilis
caused by Treponema pallidum, spread by direct contact of mucosal tissue w/ infected
lesions.
Syphillis
screen high-risk patients and all pregnant women.
Parenteral penicillin G is the drug of choice,
If patient is allergic, treat with 14 days of doxycycline or tetracycline
Benzathine penicillin G IM
The drug of choice for treatment of primary or secondary syphilis is
Primary
A solitary, painless chancre is most consistent with which of the following stages of
syphilis?
Gonorrhea
often co-infection w/ chlamydia,
Ceftriaxone 250mg IM one time ,
can use cefixime 400 mg PO once
Gonorrhea
resistant to fluroquinolones
Azithromycin 1 gram PO x 1 or Doxycycline 100mg twice daily for 7 days
When treating suspected gonorrhea in a nonpregnant patient, the patient should be
concurrently treated for chlamydia with:
3-6 months
Ongoing monitoring is essential after treating for gonorrhea. The patient should be re-
screened for gonorrhea and chlamydia in:
chlaymdia (chlamydia trachomatis)
most common reported STI in the US
co-infection w/ Gonorrhea
tx: Azithromycin 1g as a single dose for 7 days or doxycycline 100mg twice daily for 7
days
Chancroid
caused by Haemophilus ducreyi,
co- infection with HIV, syphilis, & HSV can occur
Chancroid
tx is initiated when:
1.) one or more painful ulcers
2.) negative tests for syphilis & herpes simplex virus (HSV)
3.) tender suppurative inguinal or regional lymphadenopathy
--oral azithromycin 1g or ceftriaxone 250 (IM)
or oral ciprofloxacin 500mg twice daily for 3 days
or erythromycin 500mg PO 3 times/day for 7 days
What medication would you anticipate prescribing a patient with a chancroid lesion?
azithromycin 1g PO
---ceftriaxone 250mg IM, or erythromycin 500mg PO 3 times/day for 7 days
, A pregnant woman contracts chancroid what anti-infective medication do you consider
prescribing?
Education: patients are re-examined 3-7 days after therapy is initiated.
--patients should have HIV testing done
--sexual partners are examined if they had sexual contact w/ patient in the past 20 days
Syphilis and HIV testing at 3-month intervals
Jamie was treated for a chancroid. Follow-up testing after treatment of chancroid would
be:
Ciprofloxacin (Cipro)
Which medication is Pregnancy category C in possible chancroid infections?
Granuloma Inguinale (Donoivanosis)
endemic in tropical areas such as India, New Guniea, Central Australia
Treatment: doxycycline 100mg twice daily for 3 weeks
--Treatment is a minimum 3 weeks or until all lesions have completely healed. Relapse
is common 6-18 months
Lymphogranuloma venereum (LGV)
rare sti in the United States caused by trachomatis serovars.
--tx: doxycycline 100mg twice daily for 21 days
erythromycin
A pregnant women who has contracted Lymphogranuloma venereum (LGV) would most
likely benefit most from what drug?
Metronidazole 500 mg PO bid x 7 days
Nancy presents with a complaint of vaginal discharge that when tested meets the
criteria for bacterial vaginosis. Treatment of bacterial vaginosis in nonpregnant
symptomatic women would be:
Alcohol should not be consumed during and for 1 day after metronidazole is
taken.
Besides prescribing antimicrobial therapy, patients with bacterial vaginosis require
education regarding the fact that:
Weakens condoms & diaphragms
What should you educate the patient taking clindamycin cream 2%?
Metronidazole 500mg PO twice daily for 7 days,
Metronidazole gel 0.75% one applicator full intravaginally daily for 5 days, or
Clindamycin cream 2% one applicator full intravaginally at bedtime for 7 days.
What are the different medications used to treat bacterial vaginosis?
OTC intravaginal clotrimazole, OTC intravaginal miconazole, Oral fluconazole
one-time dose,
Any of the above
Margaret presents to the clinic with vulvovaginal candidiasis. Appropriate treatment for
her would be:
Oral azole agents
Oral agents stimulate the cytochrome P450 (CYP450) enzyme system in the liver &
have potential drug interactions
oil based
----may weaken latex condoms & diaphragms also
recommended creams and suppositories for vulvovaginal candidiasis are?
Verified Solution
Syphilis
caused by Treponema pallidum, spread by direct contact of mucosal tissue w/ infected
lesions.
Syphillis
screen high-risk patients and all pregnant women.
Parenteral penicillin G is the drug of choice,
If patient is allergic, treat with 14 days of doxycycline or tetracycline
Benzathine penicillin G IM
The drug of choice for treatment of primary or secondary syphilis is
Primary
A solitary, painless chancre is most consistent with which of the following stages of
syphilis?
Gonorrhea
often co-infection w/ chlamydia,
Ceftriaxone 250mg IM one time ,
can use cefixime 400 mg PO once
Gonorrhea
resistant to fluroquinolones
Azithromycin 1 gram PO x 1 or Doxycycline 100mg twice daily for 7 days
When treating suspected gonorrhea in a nonpregnant patient, the patient should be
concurrently treated for chlamydia with:
3-6 months
Ongoing monitoring is essential after treating for gonorrhea. The patient should be re-
screened for gonorrhea and chlamydia in:
chlaymdia (chlamydia trachomatis)
most common reported STI in the US
co-infection w/ Gonorrhea
tx: Azithromycin 1g as a single dose for 7 days or doxycycline 100mg twice daily for 7
days
Chancroid
caused by Haemophilus ducreyi,
co- infection with HIV, syphilis, & HSV can occur
Chancroid
tx is initiated when:
1.) one or more painful ulcers
2.) negative tests for syphilis & herpes simplex virus (HSV)
3.) tender suppurative inguinal or regional lymphadenopathy
--oral azithromycin 1g or ceftriaxone 250 (IM)
or oral ciprofloxacin 500mg twice daily for 3 days
or erythromycin 500mg PO 3 times/day for 7 days
What medication would you anticipate prescribing a patient with a chancroid lesion?
azithromycin 1g PO
---ceftriaxone 250mg IM, or erythromycin 500mg PO 3 times/day for 7 days
, A pregnant woman contracts chancroid what anti-infective medication do you consider
prescribing?
Education: patients are re-examined 3-7 days after therapy is initiated.
--patients should have HIV testing done
--sexual partners are examined if they had sexual contact w/ patient in the past 20 days
Syphilis and HIV testing at 3-month intervals
Jamie was treated for a chancroid. Follow-up testing after treatment of chancroid would
be:
Ciprofloxacin (Cipro)
Which medication is Pregnancy category C in possible chancroid infections?
Granuloma Inguinale (Donoivanosis)
endemic in tropical areas such as India, New Guniea, Central Australia
Treatment: doxycycline 100mg twice daily for 3 weeks
--Treatment is a minimum 3 weeks or until all lesions have completely healed. Relapse
is common 6-18 months
Lymphogranuloma venereum (LGV)
rare sti in the United States caused by trachomatis serovars.
--tx: doxycycline 100mg twice daily for 21 days
erythromycin
A pregnant women who has contracted Lymphogranuloma venereum (LGV) would most
likely benefit most from what drug?
Metronidazole 500 mg PO bid x 7 days
Nancy presents with a complaint of vaginal discharge that when tested meets the
criteria for bacterial vaginosis. Treatment of bacterial vaginosis in nonpregnant
symptomatic women would be:
Alcohol should not be consumed during and for 1 day after metronidazole is
taken.
Besides prescribing antimicrobial therapy, patients with bacterial vaginosis require
education regarding the fact that:
Weakens condoms & diaphragms
What should you educate the patient taking clindamycin cream 2%?
Metronidazole 500mg PO twice daily for 7 days,
Metronidazole gel 0.75% one applicator full intravaginally daily for 5 days, or
Clindamycin cream 2% one applicator full intravaginally at bedtime for 7 days.
What are the different medications used to treat bacterial vaginosis?
OTC intravaginal clotrimazole, OTC intravaginal miconazole, Oral fluconazole
one-time dose,
Any of the above
Margaret presents to the clinic with vulvovaginal candidiasis. Appropriate treatment for
her would be:
Oral azole agents
Oral agents stimulate the cytochrome P450 (CYP450) enzyme system in the liver &
have potential drug interactions
oil based
----may weaken latex condoms & diaphragms also
recommended creams and suppositories for vulvovaginal candidiasis are?
