(Solution) NURS 6630 week 2 Discussion: Foundational
Neuroscience, latest.
Explain the agonist-to-antagonist spectrum of action of
psychopharmacologic agents, including how partial and inverse agonist
functionality may impact the efficacy of psychopharmacologic
treatments.
The traditional drug-receptor theory is a concept of how drugs abide, drug-
receptor interaction, and agonists' actions and antagonists with affinity and intrinsic
efficacy (Berg, & Clarke, 2018). Berg and Clark's study of the theory found that drugs
can act as antagonists or agonists. In contrast, agonists drugs have intrinsic efficacy and
affinity, and antagonists have only relationship and no inherent effectiveness. The
authors noted that the antagonists decrease the probability of agonist drug occupancy by
occupying the receptor cells. Still, the increased agonist concentration leads to the agonist
increasing receptor occupancy, thus blocking antagonists' effects. A full agonist generates
the maximal response a system is capable whereas a partial agonist produces a
submaximal reaction; However, a partial agonist's intrinsic efficacy is less than that of a
full agonist; full agonists can also differ in inherent efficacy. Lastly, the spare receptors
or receptor reserve is the ability of an agonist can produce a maximum response without
occupancy of the entire receptor population due to saturation of post-receptor signaling
mechanisms,
Compare and contrast the actions of g couple proteins and ion gated channels.
Ion gated receptors have a key role in the nervous system for signaling, allowing
rapid and conversion of chemical neurotransmitter messages to electrical current with ionotropic
receptors regulated by protein-protein interactions with other ion channels, G-protein coupled
receptors and intracellular proteins (Li et al., 2014). Li et al. found that the G Protein interactions
This study source was downloaded by 100000851646087 from CourseHero.com on 02-21-2023 22:45:51 GMT -06:00
https://www.coursehero.com/file/78798673/WEEK-2-DISCUSSION-class-6630docx/
, with ion channel receptors can increase the capacity of neuronal signaling cascades and represent
This study source was downloaded by 100000851646087 from CourseHero.com on 02-21-2023 22:45:51 GMT -06:00
https://www.coursehero.com/file/78798673/WEEK-2-DISCUSSION-class-6630docx/
Neuroscience, latest.
Explain the agonist-to-antagonist spectrum of action of
psychopharmacologic agents, including how partial and inverse agonist
functionality may impact the efficacy of psychopharmacologic
treatments.
The traditional drug-receptor theory is a concept of how drugs abide, drug-
receptor interaction, and agonists' actions and antagonists with affinity and intrinsic
efficacy (Berg, & Clarke, 2018). Berg and Clark's study of the theory found that drugs
can act as antagonists or agonists. In contrast, agonists drugs have intrinsic efficacy and
affinity, and antagonists have only relationship and no inherent effectiveness. The
authors noted that the antagonists decrease the probability of agonist drug occupancy by
occupying the receptor cells. Still, the increased agonist concentration leads to the agonist
increasing receptor occupancy, thus blocking antagonists' effects. A full agonist generates
the maximal response a system is capable whereas a partial agonist produces a
submaximal reaction; However, a partial agonist's intrinsic efficacy is less than that of a
full agonist; full agonists can also differ in inherent efficacy. Lastly, the spare receptors
or receptor reserve is the ability of an agonist can produce a maximum response without
occupancy of the entire receptor population due to saturation of post-receptor signaling
mechanisms,
Compare and contrast the actions of g couple proteins and ion gated channels.
Ion gated receptors have a key role in the nervous system for signaling, allowing
rapid and conversion of chemical neurotransmitter messages to electrical current with ionotropic
receptors regulated by protein-protein interactions with other ion channels, G-protein coupled
receptors and intracellular proteins (Li et al., 2014). Li et al. found that the G Protein interactions
This study source was downloaded by 100000851646087 from CourseHero.com on 02-21-2023 22:45:51 GMT -06:00
https://www.coursehero.com/file/78798673/WEEK-2-DISCUSSION-class-6630docx/
, with ion channel receptors can increase the capacity of neuronal signaling cascades and represent
This study source was downloaded by 100000851646087 from CourseHero.com on 02-21-2023 22:45:51 GMT -06:00
https://www.coursehero.com/file/78798673/WEEK-2-DISCUSSION-class-6630docx/
