CMV IGG & IGM (-)
Not previously CMV infected
CMV IgG & IgM (+)
Recent CMV infection
CMV IgG (+) & IgM (-)
Past CMV infection, not recent
Blood Type O
Universal Donor - Can receive subtype A2
Blood Type AB
Universal Recipient
Kidney Priority Listing Criteria
1) If candidate is prior living kidney donor
2) If there are 0 HLA-mismatches
Common causes of HLA Antibody production
1) Transfusions
2) Pregnancy
3) Previous transplants
Hep C Ab
Exposure to Hepatitis C
Hep B sAg
Infection with hepatitis B
Hep B sAb
Immune to hepatitis B
Hep B Core Antibody
Previous hepatitis B infection or exposure
HLA Haplotypes
A, B, DR
Rejection - Recognition step
AP Cells
Rejection - Stimulation step
T-Cells
Rejection - Defense step
CD8 and B Cells
Immunosuppression balances 3 key factors
1) Prevent rejection
2) Protect against infection and cancer
3) Guarantee efficacy
What organ is not allocated based on urgency?
Kidney
How does UNOS prioritize?
1) Medical urgency
2) Biological matching
, Liver 1A Criteria includes
1) Life expectancy <7 days
2) Hepatic artery thrombus
Heart 1A Criteria includes
Mechanical circulatory support for acute hemodynamic decompensation
Lung Allocation Score (LAS) accounts for
1) Formula estimating urgency and probability of long term survival
2) Pulmonary artery systolic pressure
3) O2 requirement
4) Need for continues mechanical ventilation
Long term risk of kidney donation
HTN
Pre-transplant education should include
1) Treatment options
2) Costs, and immunosuppression
3) Deceased donor criteria
What type of rejection is in first 6 months - likely to respond to increased
immunosuppression?
Acute cellular rejection
What urinary symptom is related to kidney transplant rejection?
Decreased UOP
All pre-transplant kidney evals should obtain
Hepatitis serologies
In the small intestine, most absorption occurs in:
Duodenum and jejunum
In early post op period for intestinal transplant, scopes are completed
Twice weekly weeks 1-6.
Nausea and vomiting may be caused by
decreased gastric motility
Which side heart catheterization is required for Lung Allocation Score?
Right heart catheterization
What is not an early complication in lung transplant?
PTLD
Contributors to chronic lung transplant rejection (Bronchiolitis obliterans)
1) RSV
2) Influenza infection
3) CMV pneumonitis
Covers doctor services for certain organ transplants
Medicare Part B
Covers transplants under certain conditions at Medicare-certified hospitals
Medicare Part A
Pays 80% of physician services, Patient pays 20%
Medicare
How long is Medicare active if obtained solely due to ESRD?
3 years
Symptoms of CMV (general, outside of tissue invasive disease)