UNE BioChem 1005 Final Exam Questions & Answers Solved 100% Correct!!

UNE BioChem 1005 Final Exam Questions & Answers Solved 100% Correct!! Somatostatin reduces the secretion of both glucagon and insulin through which of the following mechanisms? a. Somatostatin activates an activator G-protein b. Somatostatin activates MAPK cascade c. Somatostatin activates an inhibitory G-protein d. Somatostatin uses Ca+2 as a downstream signal c. Somatostatin activates an inhibitory G-protein Insulin mediated glucose uptake by muscle and adipose tissue is a result of which of the following mechanisms? a. Translocation of GLUT 4 receptors to the cell surface b. Translocation of GLUT 1 (Na+/K+ symporter) to the cell surface c. Passive diffusion d. Activation of protein kinase A a. Translocation of GLUT 4 receptors to the cell surface The alanine - glucose cycle is primarily used for which of the following purposes? a. To move ammonia from skeletal muscle to the liver b. To generate ATP for the skeletal muscle c. To move glucose from the skeletal muscle to the liver d. To move alanine from the liver to the skeletal muscle a. To move ammonia from skeletal muscle to the liver Which statement best illustrates an example of post translational gene regulation? a. Protein kinase A mediated phosphorylation of glycogen phosphorylase b. Cortisol binds a cytosolic receptor, translocates to the nucleus and binds a GRE c. Iron binding the iron response elements binding protein (IRE_BP) allowing for translation of ferritin mRNA d. DNA histone associations leading to super-coiling of DNA a. Protein kinase A mediated phosphorylation of glycogen phosphorylase Which of the following hormones is released from the liver in response to increased levels of growth hormone? a. Cortisol b. Thyroid hormone c. Somatostatin d. Insulin-like growth factor (IGF) d. Insulin-like growth factor (IGF) Autophagy is process involves degradation of protein. Under conditions of high energy (HIGH ATP) which of the following is true regarding regulation of this process? a. Akt is inactive b. AMPK is actice and phosphorylates TSC1/TSC2 Complex c. mTOR is activated d. Rheb is bound to GDP c. mTOR is activated Synthesis of which of the following lipoproteins would be elevated after a carbohydrate rich meal? a. HDL b. Chylomicrons c. LDL d. VLDL d. VLDL The synthesis of N-acetylglutamate (NAGS) is required for the activity of the urea cycle. This compound stimulates the activity of which of the following enzymes? a. Arginase b. Carbamoyl phosphate synthetase I (CPSI) c. Ornithine transcarbamoylase d. Carbamoyl phosphate synthetase II (CPSII) b. Carbamoyl phosphate synthetase I (CPSI) A male infant starts to show signs of lethargy rapidly after birth. Upon evaluation he is determined to have a deficiency in n-acetylglutamate synthesis. Based on this information, which of the following would consistent with this diagnosis? a. Elevated levels of arginine b. Decreased levels of carbamoyl phosphate c. Decreased levels of ammonia d. Elevated levels of citrulline b. Decreased levels of carbamoyl phosphate Which of the following individuals would most likely be in a positive nitrogen balance? a. An elderly individual with pneumonia b. A 10-year old boy after he fell out of a tree and broke his arm c. A healthy female in the third trimester of pregnancy c. A healthy female in the third trimester of pregnancy Glucose cannot be synthesized from the β-oxidation of even chain fatty acids because: a. gluconeogenesis is inhibited by acetyl CoA produced in the β-oxidation of fatty acids b. the acetyl CoA produced from β-oxidation is completely oxidized in the TCA cycle c. Insulin levels are elevated when fatty acids are being oxidized d. Acetyl CoA produced in the β-oxidation of fatty acids cannot be transported out of the mitochondrial matrix b. the acetyl CoA produced from β-oxidation is completely oxidized in the TCA cycle A 55-year-old male diagnosed with type 2 Diabetes and his current presentation is consistent with lack of insulin production. Serum levels of free fatty acid were elevated in this individual due to increase in which of the following enzymes? a. carnitine palmitoyl transferase 1 b. carbamoyl phosphate synthase 1 c. hormone sensitive lipase d. glutamate dehydrogenase c. hormone sensitive lipase Cholesterol is substrate for synthesis of all following compounds except: a. bile salt b. thyroid hormone c. cortisol d. aldosterone b. thyroid hormone In absence of thyroid hormone, which of the following best characterizes the activity or location of the thyroid hormone receptor? a. Is located on the cell surface as a dimer b. Is bound to DNA acting as a transcriptional repressor c. Is free within the cytosol of the cell d. Is bound to DNA acting as a transcriptional activator b. Is bound to DNA acting as a transcriptional repressor Thyrotropin-releasing hormone (TRH) can stimulate release of thyroid hormone. TRH is released from which of the following organs? a. Thyroid gland b. Pituitary c. Liver d. Hypothalamus d. Hypothalamus Alanine aminotransferase requires which following cofactors for activity? a. pyridoxal phosphate b. folate c. cobalamin d. thiamine a. pyridoxal phosphate