UNE medical biochemistry Unit 2 Test
If unregulated, which of the following pairs of enzymes would represent a futile
cycle?
Fructose 1,6 bisphosphatase and phosphofructokinase-1
Rotenone blocks complex 1 in the ETC. This increases levels of NADH and would
likely impair the function of which of the following enzymes?
Pyruvate dehydrogenase complex
Newborn screening shows a biotinidase deficiency in a 2-day old infant. This
deficienty impairs the infant's ability to reuse and recycle biotin. Due to this
enzymatic deficiency, the activity of which of the following enzymes is likely
impaired?
pyruvate carboxylase
An individual is recently diagnosed with Type 2 diabetes. In this individual,
hyperglycemia may in part be due to inactivity of which of the following glucose
transporters on skeletal muscle?
Glut 4 (insulin dependent)
The skeletal muscle primarily provides substrate for gluconeogenesis through
which of the following processes?
protein catabolism
Alanine can be shuttled from the skeletal muscle to the liver where it is
deaminated to produce pyruvate. When glucagon is high, pyruvate is primarily
used as a substrate for which of the following pathways?
gluconeogenesis
Aldolase B facilitaes a reaction that cleaves fructose 1-phosphate into two 3-
carbon molecules that will enter glycolysis as which of the following
compounds?
glyceraldehyde-3-phosphate
Within the RBC, NADPH is used for which of the following processes?
to re-reduce glutathione
Galactose-1-phosphate is initially converted to glucose-1-phosphate and requires
which of the following compounds?
UDP-glucose
Which of the following are the two primary products of the Pentose Phosphate
pathway?
Ribose-5-phosphate and NADPH
Which of the following enzymes is involved in the non-oxidative portion of the
Pentose Phosphate Pathway?
transaldolase
A patient presents with a deficiency of thiamine. If this patient's liver cells are
compared to normal liver cells, which of the following products would be
decreased in the patient's cells (compared to the normal cells), if the cells are
only given glucose as a fuel?
CO2 (lack of thiamine would reduce activity of PDC - as a result, most pyruvate would
be diverted to lactate instead of acetyl-CoA)
If unregulated, which of the following pairs of enzymes would represent a futile
cycle?
Fructose 1,6 bisphosphatase and phosphofructokinase-1
Rotenone blocks complex 1 in the ETC. This increases levels of NADH and would
likely impair the function of which of the following enzymes?
Pyruvate dehydrogenase complex
Newborn screening shows a biotinidase deficiency in a 2-day old infant. This
deficienty impairs the infant's ability to reuse and recycle biotin. Due to this
enzymatic deficiency, the activity of which of the following enzymes is likely
impaired?
pyruvate carboxylase
An individual is recently diagnosed with Type 2 diabetes. In this individual,
hyperglycemia may in part be due to inactivity of which of the following glucose
transporters on skeletal muscle?
Glut 4 (insulin dependent)
The skeletal muscle primarily provides substrate for gluconeogenesis through
which of the following processes?
protein catabolism
Alanine can be shuttled from the skeletal muscle to the liver where it is
deaminated to produce pyruvate. When glucagon is high, pyruvate is primarily
used as a substrate for which of the following pathways?
gluconeogenesis
Aldolase B facilitaes a reaction that cleaves fructose 1-phosphate into two 3-
carbon molecules that will enter glycolysis as which of the following
compounds?
glyceraldehyde-3-phosphate
Within the RBC, NADPH is used for which of the following processes?
to re-reduce glutathione
Galactose-1-phosphate is initially converted to glucose-1-phosphate and requires
which of the following compounds?
UDP-glucose
Which of the following are the two primary products of the Pentose Phosphate
pathway?
Ribose-5-phosphate and NADPH
Which of the following enzymes is involved in the non-oxidative portion of the
Pentose Phosphate Pathway?
transaldolase
A patient presents with a deficiency of thiamine. If this patient's liver cells are
compared to normal liver cells, which of the following products would be
decreased in the patient's cells (compared to the normal cells), if the cells are
only given glucose as a fuel?
CO2 (lack of thiamine would reduce activity of PDC - as a result, most pyruvate would
be diverted to lactate instead of acetyl-CoA)
