HSC4504 Final Exam Practice Test Questions and
Correct Answers, 248 Q&A. With Complete Solution
2024.
An example of innate immunity is
NK cells
Which of the following correctly describe innate immunity
Is always present in healthy individuals
The body produces its own antibodies with which form of immunity
Active immunity
Infection by a respiratory virus produces
Active immunity
MALT is an example of a secondary lymphoid organ
True
Both positive and negative selection can occur in the lymph nodes
False
The functioning of the thymus is better in
Healthy 18 year old male
Which of the following statements is FALSE about lymph nodes
Lymph nodes participate in positive selection
An individual can live a normal life without functional bone marrow
False
An example of a professional antigen presenting cell is
Dendritic cell
Which of the following statements regarding complement is TRUE
a) Complement is present in serum in the inactive form. b) Complement is sequentially
activated.
c) Complement is essential to proper functioning of the immune system and promoting
inflammation
(All of the above)
The classical pathway is part of the innate immune response and can be activated
directly by microorganisms
False
Which of the following complement pathways is part of the innate immune
system and can be directly activated by microorganisms
Alternative
C3a and C5a can produce anaphylactic reactions
True
The formation of the complement membrane attack complex (small round
bubbles on surface of bacteria) kills the cell by
creating pores in the cell membrane
Inflammation is an accessory to the immune system that exhibits specificity
,False
Giant cells may be produced during chronic inflammation
True
An inflammed area described as calor is
hot to the touch
Which of the following statements is FALSE about antibodies
Antibodies are active against intracellular pathogens
Similarities of T cell receptors and B cell receptors include
Great diversity of the receptors
Mature B cells that are stimulated by transform into cells that produce
antigens, plasma, antibodies
Antigen binding is the primary function of antibodies
True
Isotype switching is the production of a different heavy chain class by B cells
during differentiation
True
Fab regions of antibodies bind
Antigen
Which antibody class is found in body secretions such as saliva
IgA
What neutralizing antibody class rises in the secondary immune response and
can remain elevated for life
IgG
Which class of antibodies is secreted in the structural form of a pentamer
IgM
Isotype switching is usually IgG to IgM
False
Protein antigens are more likely to elicit a T cell response than lipid antigens
True
An epitope must be bound to a MHC molecule to be recognized by a T cell
receptor
True
Lipids are T independent antigens
True
Superantigens can produce mass activation of Tcells
True
Polysaccharides are examples of Tdependent antigens
False
Most regulatory T cells are
CD4+
Nucleated cells present peptides derived from proteins on MHC Class I molecules
Intracellular
cells assist the immune response against helminth infections
Th2
Which of the following statements about cytokines is FALSE
Cytokines have low affinity and are potent only at high concentrations
, Which of the following statements about cytokines are TRUE
Cytokines are low molecular weight proteins.
Cytokines are important in nearly all biologic processes, such as cell growth,
inflammation, and tissue repair.
Cytokines have multiple functions.
Cytokines are mediators of both adaptive and innate immunity.
(All of the above)
Complement deficiency may result in both increased susceptibility to infections
and the development of autoimmunity
True
Repeated activation of mature T cells by self antigens may cause apoptosis in the
self reactive T cells
True
IgE antibodies are involved in which type of hypersensitivity reaction
Type I
Immediate hypersensitivity reactions develop as a consequence of the activation
of what cells
TH2
Type II hypersensitivity reactions involve
IgG
This primary immunodeficiency is characterized by the impaired production of
major histocompatability complex molecules. Patients with this disease have
compromised antigen presentation and few functional CD4+ T cells due to
impaired antigen recognition. What disease am I?
Bare lymphocyte syndrome
This type of primary immunodeficiency is rare except when consanguinity is
involved. Patients with this disease have decreased activity of an enzyme that
helps cells remove toxic byproducts of metabolism from cells, resulting in the
death of immune cells. What disease am I?
ADA deficiency
This primary immunodeficiency is extremely rare in the population, with less than
200 cases reported. Patients with this disease have impaired lymphocytes,
macrophages and neutrophils that do not allow these cells to travel to the site of
an infection, and consequently many patients succumb to infections before the
age of 2. What disease am I?
LAD I
Immune complexes floating free in the blood are an example of Type 3
hypersensitivity
False
Delayed typed hypersensitivity is a what reaction
Type IV
Which form(s) of donor organ rejection are mediated by antibodies
Hyperacute
Direct antigen recognition is responsible for acute organ rejection
True
Correct Answers, 248 Q&A. With Complete Solution
2024.
An example of innate immunity is
NK cells
Which of the following correctly describe innate immunity
Is always present in healthy individuals
The body produces its own antibodies with which form of immunity
Active immunity
Infection by a respiratory virus produces
Active immunity
MALT is an example of a secondary lymphoid organ
True
Both positive and negative selection can occur in the lymph nodes
False
The functioning of the thymus is better in
Healthy 18 year old male
Which of the following statements is FALSE about lymph nodes
Lymph nodes participate in positive selection
An individual can live a normal life without functional bone marrow
False
An example of a professional antigen presenting cell is
Dendritic cell
Which of the following statements regarding complement is TRUE
a) Complement is present in serum in the inactive form. b) Complement is sequentially
activated.
c) Complement is essential to proper functioning of the immune system and promoting
inflammation
(All of the above)
The classical pathway is part of the innate immune response and can be activated
directly by microorganisms
False
Which of the following complement pathways is part of the innate immune
system and can be directly activated by microorganisms
Alternative
C3a and C5a can produce anaphylactic reactions
True
The formation of the complement membrane attack complex (small round
bubbles on surface of bacteria) kills the cell by
creating pores in the cell membrane
Inflammation is an accessory to the immune system that exhibits specificity
,False
Giant cells may be produced during chronic inflammation
True
An inflammed area described as calor is
hot to the touch
Which of the following statements is FALSE about antibodies
Antibodies are active against intracellular pathogens
Similarities of T cell receptors and B cell receptors include
Great diversity of the receptors
Mature B cells that are stimulated by transform into cells that produce
antigens, plasma, antibodies
Antigen binding is the primary function of antibodies
True
Isotype switching is the production of a different heavy chain class by B cells
during differentiation
True
Fab regions of antibodies bind
Antigen
Which antibody class is found in body secretions such as saliva
IgA
What neutralizing antibody class rises in the secondary immune response and
can remain elevated for life
IgG
Which class of antibodies is secreted in the structural form of a pentamer
IgM
Isotype switching is usually IgG to IgM
False
Protein antigens are more likely to elicit a T cell response than lipid antigens
True
An epitope must be bound to a MHC molecule to be recognized by a T cell
receptor
True
Lipids are T independent antigens
True
Superantigens can produce mass activation of Tcells
True
Polysaccharides are examples of Tdependent antigens
False
Most regulatory T cells are
CD4+
Nucleated cells present peptides derived from proteins on MHC Class I molecules
Intracellular
cells assist the immune response against helminth infections
Th2
Which of the following statements about cytokines is FALSE
Cytokines have low affinity and are potent only at high concentrations
, Which of the following statements about cytokines are TRUE
Cytokines are low molecular weight proteins.
Cytokines are important in nearly all biologic processes, such as cell growth,
inflammation, and tissue repair.
Cytokines have multiple functions.
Cytokines are mediators of both adaptive and innate immunity.
(All of the above)
Complement deficiency may result in both increased susceptibility to infections
and the development of autoimmunity
True
Repeated activation of mature T cells by self antigens may cause apoptosis in the
self reactive T cells
True
IgE antibodies are involved in which type of hypersensitivity reaction
Type I
Immediate hypersensitivity reactions develop as a consequence of the activation
of what cells
TH2
Type II hypersensitivity reactions involve
IgG
This primary immunodeficiency is characterized by the impaired production of
major histocompatability complex molecules. Patients with this disease have
compromised antigen presentation and few functional CD4+ T cells due to
impaired antigen recognition. What disease am I?
Bare lymphocyte syndrome
This type of primary immunodeficiency is rare except when consanguinity is
involved. Patients with this disease have decreased activity of an enzyme that
helps cells remove toxic byproducts of metabolism from cells, resulting in the
death of immune cells. What disease am I?
ADA deficiency
This primary immunodeficiency is extremely rare in the population, with less than
200 cases reported. Patients with this disease have impaired lymphocytes,
macrophages and neutrophils that do not allow these cells to travel to the site of
an infection, and consequently many patients succumb to infections before the
age of 2. What disease am I?
LAD I
Immune complexes floating free in the blood are an example of Type 3
hypersensitivity
False
Delayed typed hypersensitivity is a what reaction
Type IV
Which form(s) of donor organ rejection are mediated by antibodies
Hyperacute
Direct antigen recognition is responsible for acute organ rejection
True
