lOMoAR cPSD| 36357603
THE IMMUNE RESPONSE TO MALARIA MICRO
ORGANISISMS INFECTION AND IMMUNITY
ALLL LECTURE NOTES COVERING IMMUNE RESPONSE TO MALARIA – CHARACTERISTICS OF
DIFFERENT SPECIES AND THEIR DISEASES AND PATHOGENESIS AND ALSO CONTAINS DIAGRAM WITH
HIGHLIGHTED IMPORTANT COMPONENTS. IMPORTANT FOR EXAM GUANTEED A+ GRADE
• use malaria as eg infection with which to describe the course of an immune
response.
• describe how the immune system recognises the malaria parasite.
• describe the innate and adaptive immune responses triggered by malaria.
• explain how the immune response can contribute to disease.
1. Plasmodium life cycle
mosquito injects sporozoites (infective forms) into dermis migrate via
dermis looking for blood vessel squeeze through get to circulation, move
around the body go to liver to infect liver cells stay there for 7 days
undergoing asexual replication = amplification of parasites release of
merozoites (infective forms that invade blood cells) get into blood cells
blood cycle: merozoites become schizonts, trophozoites division in RBC
schizonts rupture and release meroziotes infection
Most time parasites spend time in RBC cycle – time depends on species.
`
, lOMoAR cPSD| 36357603
1. How skin and liver stage parasites trigger immune response.
How blood-stage parasites trigger immune response.
`
THE IMMUNE RESPONSE TO MALARIA MICRO
ORGANISISMS INFECTION AND IMMUNITY
ALLL LECTURE NOTES COVERING IMMUNE RESPONSE TO MALARIA – CHARACTERISTICS OF
DIFFERENT SPECIES AND THEIR DISEASES AND PATHOGENESIS AND ALSO CONTAINS DIAGRAM WITH
HIGHLIGHTED IMPORTANT COMPONENTS. IMPORTANT FOR EXAM GUANTEED A+ GRADE
• use malaria as eg infection with which to describe the course of an immune
response.
• describe how the immune system recognises the malaria parasite.
• describe the innate and adaptive immune responses triggered by malaria.
• explain how the immune response can contribute to disease.
1. Plasmodium life cycle
mosquito injects sporozoites (infective forms) into dermis migrate via
dermis looking for blood vessel squeeze through get to circulation, move
around the body go to liver to infect liver cells stay there for 7 days
undergoing asexual replication = amplification of parasites release of
merozoites (infective forms that invade blood cells) get into blood cells
blood cycle: merozoites become schizonts, trophozoites division in RBC
schizonts rupture and release meroziotes infection
Most time parasites spend time in RBC cycle – time depends on species.
`
, lOMoAR cPSD| 36357603
1. How skin and liver stage parasites trigger immune response.
How blood-stage parasites trigger immune response.
`
