Test Bank for Pharmacology and the Nursing
Process 10th Edition By Linda Lilley, Shelly
Collins, Julie Snyder Chapter 1-58 |Complete
Guide 2022
1). The pka (for the cooh group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. of these, which will be absorbed to the greatest
extent from the stomach (ph = 1.0)?
Ans: neothyroxine
2). The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent
manner. what is this called?
Ans: active transport
3). Phase ii conjugates typically have the following property/properties
Ans: rapidly excreted in the urine
4). A drug with a half-life of 2 hours is administered by continuous intravenous infusion. how
long will it take for the drug to reach 50% of its steady state concentration?
Ans: 2 hours
5). Caffeine is eliminated primarily by metabolism and with first order kinetics. the half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. the volume of
distribution is 0.60 l/kg. joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. he has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
what is the clearance value (cl) of caffeine in a normal individual?
Ans: 0.083 L/hr/kg
6). Which of the following routes is most likely to be affected by the first-pass effect?
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, Ans: oral
7). A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/ml.
the apparent volume of distribution is (rapid distribution and negligible elimination prior to
measuring the peak plasma level):
Ans: 15 L
8). Which of the following are routes of drug clearance?
-renal
-sweat
-intestines
Ans: all of the above
9). What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes
Ans: all of the above
10). What type of receptor is the muscarinic receptor?
Ans: G-protein coupled receptor
11). For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the
time-dependent dealkylation process called yielding an enzyme refractory toward
reactivation?
Ans: aging
12). Muscarinic receptors bind
Ans: acetylcholine
13). Which of the following is a clinical use for a muscarinic agonist?
Ans: "switching on" the urinary tract after surgery
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, 14). Indirect cholinergic agonists cause
Ans: inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels
15). Which of the following is characteristic of the sympathetic nervous system?
Ans: responded predominate during physical activity or when experiencing fright
16). A patient with an acute attack of glaucoma is treated with pilocarpine. the primary reason
for its effectiveness in this condition is its:
Ans: ability to lower intraocular pressure
17). Put the following steps in the correct order for neurotransmission at the cholinergic
neuron
Ans: 1. acetylcholine is synthesized from choline and acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase
18). The autonomic nervous system innervates all of these except
Ans: skeletal muscle
19). A soldiers' unit has come under attack with a nerve agent. the symptoms exhibited are
skeletal muscle paralysis, profuse brachial secretions, miosis, bradycardia, and
convulsions. the alarm indicates exposure to an organophosphate. what is the correct
treatment?
Ans: administer atropine and 2-PAM (pralidoxime)
20). A study examining how a drug is distributed throughout the body and how the drug is
changed before eliminated is an example of
Ans: pharmacokinetics
21). Knowing that all three drugs interact with the same receptor, which drug is a competitive
antagonist?
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Process 10th Edition By Linda Lilley, Shelly
Collins, Julie Snyder Chapter 1-58 |Complete
Guide 2022
1). The pka (for the cooh group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. of these, which will be absorbed to the greatest
extent from the stomach (ph = 1.0)?
Ans: neothyroxine
2). The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent
manner. what is this called?
Ans: active transport
3). Phase ii conjugates typically have the following property/properties
Ans: rapidly excreted in the urine
4). A drug with a half-life of 2 hours is administered by continuous intravenous infusion. how
long will it take for the drug to reach 50% of its steady state concentration?
Ans: 2 hours
5). Caffeine is eliminated primarily by metabolism and with first order kinetics. the half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. the volume of
distribution is 0.60 l/kg. joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. he has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
what is the clearance value (cl) of caffeine in a normal individual?
Ans: 0.083 L/hr/kg
6). Which of the following routes is most likely to be affected by the first-pass effect?
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, Ans: oral
7). A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/ml.
the apparent volume of distribution is (rapid distribution and negligible elimination prior to
measuring the peak plasma level):
Ans: 15 L
8). Which of the following are routes of drug clearance?
-renal
-sweat
-intestines
Ans: all of the above
9). What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes
Ans: all of the above
10). What type of receptor is the muscarinic receptor?
Ans: G-protein coupled receptor
11). For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the
time-dependent dealkylation process called yielding an enzyme refractory toward
reactivation?
Ans: aging
12). Muscarinic receptors bind
Ans: acetylcholine
13). Which of the following is a clinical use for a muscarinic agonist?
Ans: "switching on" the urinary tract after surgery
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, 14). Indirect cholinergic agonists cause
Ans: inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels
15). Which of the following is characteristic of the sympathetic nervous system?
Ans: responded predominate during physical activity or when experiencing fright
16). A patient with an acute attack of glaucoma is treated with pilocarpine. the primary reason
for its effectiveness in this condition is its:
Ans: ability to lower intraocular pressure
17). Put the following steps in the correct order for neurotransmission at the cholinergic
neuron
Ans: 1. acetylcholine is synthesized from choline and acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase
18). The autonomic nervous system innervates all of these except
Ans: skeletal muscle
19). A soldiers' unit has come under attack with a nerve agent. the symptoms exhibited are
skeletal muscle paralysis, profuse brachial secretions, miosis, bradycardia, and
convulsions. the alarm indicates exposure to an organophosphate. what is the correct
treatment?
Ans: administer atropine and 2-PAM (pralidoxime)
20). A study examining how a drug is distributed throughout the body and how the drug is
changed before eliminated is an example of
Ans: pharmacokinetics
21). Knowing that all three drugs interact with the same receptor, which drug is a competitive
antagonist?
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