NAME (PRINT):
Last/Surname First /Given Name
STUDENT #: SIGNATURE:
UNIVERSITY OF TORONTO MISSISSAUGA
DECEMBER 2018 FINAL EXAMINATION
BIO380H5F
Human Development
Teddy Erclik
Duration - 3 hours
Aids: None
The University of Toronto Mississauga and you, as a student, share a commitment to
academic integrity. You are reminded that you may be charged with an academic
offence for possessing any unauthorized aids during the writing of an exam. Clear,
sealable, plastic bags have been provided for all electronic devices with storage,
including but not limited to: cell phones, SMART devices, tablets, laptops, calculators,
and MP3 players. Please turn off all devices, seal them in the bag provided, and
place the bag under your desk for the duration of the examination. You will not be
able to touch the bag or its contents until the exam is over.
If, during an exam, any of these items are found on your person or in the area of your
desk other than in the clear, sealable, plastic bag, you may be charged with an
academic offence. A typical penalty for an academic offence may cause you to fail
the course.
Please note, once this exam has begun, you CANNOT re-write it.
This exam has two parts:
Part I, 55 Multiple Choice Questions (55 marks)
Part II, 7 Short Answer Questions (45 marks)
, BIO380
PART I: MULTIPLE CHOICE QUESTIONS (55 marks; 1 mark each)
Choose one option that best answers the question. Fill in your scantron sheet for all
questions and remember to include your first and last name and student number on your
scantron and your test.
1.
The
clock-‐wavefront
model
for
somitogenesis
proposes
that:
A)
The
differential
expression
of
Hox
genes
along
the
A/P
axis
drives
the
wave
of
somitogenesis
B)
A
moving
boundary
between
gradients
of
FGF
and
retinoic
acid
regulates
somitogenesis
C)
A
segmentation
clock
involving
Fgf8
signaling
converts
mesoderm
into
somites
D)
A
wave
of
Shh
from
the
notochord
drives
somitogenesis
2.
Which
of
the
following
statements
regarding
somites
is
false?
A)
The
newly
formed
somite
contains
2
main
compartments
B)
Somites
form
in
a
cranial-‐caudal
direction
C)
Somites
develop
from
the
paraxial
mesoderm
D)
The
scleretome
generates
rib
cartilage
E)
The
myotome
contributes
to
limb
muscles
3.
What
do
the
transcription
factors
Id
and
E12
share
in
common?
A)
Both
are
required
for
muscle-‐specific
gene
activation
B)
Both
work
better
when
they
dimerize
with
E12
C)
Both
can
form
heterodimers
with
MyoD
D)
Both
are
activated
by
myostatin
signaling
4.
Notch
functions
during
somitogenesis
to:
A)
Antagonize
the
Fgf8
morphogen
gradient
B)
Generate
somite
boundaries
C)
Prevent
the
premature
end
of
axis
elongation
D)
Negatively
regulate
retinoic
acid
expression
5.
What
gene’s
loss-‐of-‐function
produces
an
overly
muscular
dog?
A)
Myostatin
B)
MyoD
C)
Myf-‐5
D)
Myf-‐6
E)
Myogenin
6.
The
rib
arises
from
which
mesodermal
tissue?
A)
The
intermediate
mesoderm
B)
The
dermatome
C)
The
lateral
plate
mesoderm
D)
The
sclerotome
E)
None
of
the
above
2
Last/Surname First /Given Name
STUDENT #: SIGNATURE:
UNIVERSITY OF TORONTO MISSISSAUGA
DECEMBER 2018 FINAL EXAMINATION
BIO380H5F
Human Development
Teddy Erclik
Duration - 3 hours
Aids: None
The University of Toronto Mississauga and you, as a student, share a commitment to
academic integrity. You are reminded that you may be charged with an academic
offence for possessing any unauthorized aids during the writing of an exam. Clear,
sealable, plastic bags have been provided for all electronic devices with storage,
including but not limited to: cell phones, SMART devices, tablets, laptops, calculators,
and MP3 players. Please turn off all devices, seal them in the bag provided, and
place the bag under your desk for the duration of the examination. You will not be
able to touch the bag or its contents until the exam is over.
If, during an exam, any of these items are found on your person or in the area of your
desk other than in the clear, sealable, plastic bag, you may be charged with an
academic offence. A typical penalty for an academic offence may cause you to fail
the course.
Please note, once this exam has begun, you CANNOT re-write it.
This exam has two parts:
Part I, 55 Multiple Choice Questions (55 marks)
Part II, 7 Short Answer Questions (45 marks)
, BIO380
PART I: MULTIPLE CHOICE QUESTIONS (55 marks; 1 mark each)
Choose one option that best answers the question. Fill in your scantron sheet for all
questions and remember to include your first and last name and student number on your
scantron and your test.
1.
The
clock-‐wavefront
model
for
somitogenesis
proposes
that:
A)
The
differential
expression
of
Hox
genes
along
the
A/P
axis
drives
the
wave
of
somitogenesis
B)
A
moving
boundary
between
gradients
of
FGF
and
retinoic
acid
regulates
somitogenesis
C)
A
segmentation
clock
involving
Fgf8
signaling
converts
mesoderm
into
somites
D)
A
wave
of
Shh
from
the
notochord
drives
somitogenesis
2.
Which
of
the
following
statements
regarding
somites
is
false?
A)
The
newly
formed
somite
contains
2
main
compartments
B)
Somites
form
in
a
cranial-‐caudal
direction
C)
Somites
develop
from
the
paraxial
mesoderm
D)
The
scleretome
generates
rib
cartilage
E)
The
myotome
contributes
to
limb
muscles
3.
What
do
the
transcription
factors
Id
and
E12
share
in
common?
A)
Both
are
required
for
muscle-‐specific
gene
activation
B)
Both
work
better
when
they
dimerize
with
E12
C)
Both
can
form
heterodimers
with
MyoD
D)
Both
are
activated
by
myostatin
signaling
4.
Notch
functions
during
somitogenesis
to:
A)
Antagonize
the
Fgf8
morphogen
gradient
B)
Generate
somite
boundaries
C)
Prevent
the
premature
end
of
axis
elongation
D)
Negatively
regulate
retinoic
acid
expression
5.
What
gene’s
loss-‐of-‐function
produces
an
overly
muscular
dog?
A)
Myostatin
B)
MyoD
C)
Myf-‐5
D)
Myf-‐6
E)
Myogenin
6.
The
rib
arises
from
which
mesodermal
tissue?
A)
The
intermediate
mesoderm
B)
The
dermatome
C)
The
lateral
plate
mesoderm
D)
The
sclerotome
E)
None
of
the
above
2
