BOC HEMATOLOGY questions and complete solutions

BOC Hematology 1) The light-colored zone adjacent to the nucleus in a plasmacyte is the: a. ribosome b. chromatin c. mitochondria d. Golgi area ANSWERS:-d (Morphological identifiable perinuclear halo.) 3) The majority of the iron in an adult is found as a constituent of: a. hemoglobin b. hemosiderin c. myoglobin d. transferrin ANSWERS:-a (2/3 iron in body bound to Hgb.) 4) The main function of the hexose monophosphate shunt in the erythrocyte is to: a. regulate the level of 2,3-DPG b. provide reduced glutathione to prevent oxidation of hemoglobin c. prevent the reduction of heme iron d. provide energy for membrane maintenance ANSWERS:-b (Maintains in Fe++ form by way of reduced glutathione.) 10) In order for hemoglobin to combine reversibly with oxygen, the iron must be: a. complexed with haptoglobin b. freely circulating in the cytoplasm c. attached to transferrin d. in the ferrous state ANSWERS:-d (Functional form of Fe [reduced].) 11) In which of the following disease states are teardrop cells and abnormal platelets most characteristically seen? a. hemolytic anemia b. multiple myeloma c. G-6-PD deficiency d. myeloid metaplasia ANSWERS:-d (RBC morphology; disease state identification.) 13) In the normal adult, the spleen acts as a site for: a. storage of RBCs b. production of RBCs c. synthesis of erythropoietin d. removal of imperfect and aging cells ANSWERS:-d (Major site of destruction of senescent red blood cells.) 14) After the removal of RBCs from the circulation hemoglobin is broken down into: a. iron, prophyrin, amino acids b. iron, protoporphyrin, globin c. heme, protoporphyrin, amino acids d. heme, hemosiderin, globin ANSWERS:-b (Normal degradation products of red blood cells.) 15) Heinz bodies are: a. readily identified with polychrome stains b. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes c. closely associated with spherocytes d. denatured hemoglobin inclusion that are readily removed by the spleen ANSWERS:-d (Formed with oxidization of Fe and formation of methemoglobin.) 17) Cells for the transport of O2 and CO2 are: a. erythrocytes b. granulocytes c. lymphocytes d. thrombocytes ANSWERS:-a (Primary functions of red blood cells.) 18) Erythropoietin acts as: a. shorten the replication time of the granulocytes b. stimulate RNA synthesis of erythroid cells