PCOL 824 Test 2 Questions with Correct Answers

PCOL 824 Test 2 Questions with Correct Answers Types of bonds often seen in Drug-ReceptorInteractions - Answer-Electrostatic Interactions: (strongest first) 1) Salt Bridges (ion-ion) (full charge on full charge Na+Cl-, much stronger) 2) Pi-Cation (ion-dipole) the ion-dipole interaction (i.e. a fully charged species interacting with the opposite charge of a dipole) 3) Neutral H-Bonds (dipole-dipole) 4) Van der waals (C to C) *Aliphatic chains to Aliphatic chains Aliphatic chains to aromatic Edge on *Face to face (Pi-stacking [of aromatic rings]) Concepts of medicinal chemistry 5 terms - Answer-physicochemical properties metabolism Ligand (intermolecular drug)-receptor binding pharmacophores Structure-activity relationships (SAR) ACPE Standards: Definition of Medicinal Chemistry - Answer-"Chemical basis of drug action and behavior in vivo andi n vitro, with an emphasis on pharmacophore recognition and the application of physicochemical properties, structure-activity relationships, intermolecular drug-receptor interactions and metabolism to therapeutic decision-making." pharmacophore definition - Answer-a molecular framework that carries (phoros) the essential features responsible for a drug's biological activity" Features: Donor, Acceptor, Positive, Charge, Aromatic, Hydrophobic, Acid, Base ABA pharmacophore - Answer-Aromatic Base Aromatic Pharmacognosy - Answer-initially referred to as the investigation of medicinal substances of plant, animal or mineral origin in their crude or unprepared state, used in the form of teas, poultices and other types of formulation Natural products - Answer-chemical compounds produced by a living organism—that is, found in nature the dawn of SAR-based drugdiscovery and origins of medicinal chemistry - Answer-By the middle of the 20th century, the chemical components (i.e. natural product active ingredients) were being increasingly identified and subsequently modified to discover improved therapeutics Many view the discovery of morphine +associated data as the beginning of modern day medicinal chemistry.