CCTC Transplant pharmacology Exam 2024 Questions and Answers.

CCTC Transplant pharmacology Exam 2024 Questions and Answers. Calcineurin inhibitors - Answer Cyclosporine or Sandimmune (Neoral, Gengraf) & Tacrolimus or hecoria (Prograf) MOA of Tacrolimus (Prograf) - Answer binds to fkbp12 to inhibit interleukin 2 production & release. Which inhibits cytotoxic T cells. MOA of Cyclosporine (Neoral, Gengraf) - Answer Binds to cyclophylin to inhibit interleukin 2 production & release. Which inhibits cytotoxic T cells. side effects of tacrolimus - Answer Neurotoxicity (HA, tremors, anxiety, confusion, sleep disturbance) Nephrotoxicity Diarrhea HTN Hyperkalemia Hyperglycemia Hypomagnesemia HUS Hypophosphatemia. tacrolimus & cyclosporine are synergistic with which meds? - Answer Sirolimus NSAID'S how is tacrolimus & Sirolimus metabolized? - Answer Through cytochrome p450 3A4 enzyme pathway in liver. How many hours is tacrolimus & cyclosporine troughs? - Answer 11-12 hour trough level. absorption of tacrolimus & sirolimus - Answer Decreased by food, especially fatty foods. Best absorbed on empty stomach. If taken with food, always take with food.