Hematologic Malignancies (PEARLS) (Smarty PANCE) (Latest 2023 / 2024) Actual Questions and Answers 100% Correct

Hematologic Malignancies (PEARLS) (Smarty PANCE) (Latest 2023 / 2024) Actual Questions and Answers 100% Correct 1. *A 3-7 y/o child* with lymphadenopathy,bone pain,bleeding, and fever.Bonemarrow 20% blasts.What's the Dx? Answer: Acute lymphocytic leukemia (ALL) 2. A 60-year-old male complains of fatigue, blood tests demonstrate severe anemia, *SMUDGE CELLS* on peripheral smear, mature lymphocytes.What'sthe Dx? Answer: Chronic Lymphocytic Leukemia (CLL) 3. A 54-year-old patient with anemia, nosebleeds, bruising, thrombocytopenia, and neutropenia. Splenomegaly, gingival hyperplasia, and bone pain myeloblasts in bone marrow 20% and *Auer Rods*.What's the Dx? Answer: AcuteMyeloid Leukemia (AML) 4. A 64-year-old with strikingly increased WBC count, and hyperuricemia. Genetic testing demonstrates *translocation of chromosomes 9 and 22*.What'sthe Dx? Answer: Chronic Myeloid Leukemia (CML) 5. A patient presents with fever, chills, and night sweats for 1 month. *Pain- less enlarged posterior cervical and supraclavicular lymph nodes* bilaterally. *CXR - mediastinal adenopathy.* Excisional biopsy of lymph node shows *Reed-Sternberg cells*.What's the Dx? Answer: Hodgkin's Lymphoma 6. An HIV Patient with GI symptoms and *painless peripheral lymphadenopathy*.What's the Dx? Answer: Non-Hodgkin Lymphoma 7. A 65-year-old with bone and back pain refractory to treatments. Serum protein electrophoresis *monoclonal protein Spike (IgG or IgA).* Urine protein electrophoresis *Bence Jones Protein.* Skull X-ray demonstrates *lytic(punched out) bone lesions*.What's the Dx? Answer: Multiple myeloma 8. What is lymphoma? Answer: A heterogeneous group of malignancies of lymphocytesthat usually arise in lymph nodes but may originate in any organ 9. What are the 2 broad categories of lymphomas? Answer: Hodgkin disease and NHL