Question regarding Topic 2 can be found in the following past papers of:
1) International A Level Syllabus 2018
Question
Month Year Unit Question Theme Description of the Question
Number
DNA and RNA Comparison of structures of DNA
January 2019 1 3
Structures and RNA.
Membrane Study of membrane permeability
January 2019 1 5
Permeability and effects of cholesterol.
Analyzing the components found in
Polynucleotide
January 2020 1 1 DNA and mRNA using a Venn
Structure
diagram.
Investigating the function of the
Paramecium and
January 2020 1 5 contractile vacuole in paramecia in
Contractile Vacuole
different solutions.
Cystic Fibrosis Cystic fibrosis, its effects on trachea
January 2020 1 8
Analysis structure, and trends in prevalence.
Concept of polygenic inheritance,
Polygenic
January 2020 2 3 height prediction based on parental
Inheritance
heights
Components of polynucleotides,
January 2021 1 1 DNA and RNA mononucleotide structure,
complementary base pairing
Gene definition, mutations causing
January 2022 1 4 Cystic Fibrosis
cystic fibrosis, and carrier screening
Sickle cell disease mutation, p50
January 2022 1 8 Sickle Cell Disease value calculation, lifespan of red
blood cells in sickle cell disease
mRNA Vaccine Understanding mRNA vaccine and
January 2022 2 3
Mechanism its cellular interaction.
Polygenic Explaining variation in skin color
January 2022 2 6
Inheritance due to genetics.
Water Potential in Experimenting with water potential
January 2022 3 3
Carrots using carrot cylinders.
The use of nuclear DNA and
DNA Analysis in
mitochondrial DNA in distinguishing
January 2022 4 5 Species
bird species, and the application of
Identification
PCR in DNA amplification.
Questions on DNA base sequences,
DNA and Protein amino acids, and protein synthesis,
June 2019 1 3
Synthesis including calculating and explaining
genetic codes.
, Question
Month Year Unit Question Theme Description of the Question
Number
Questions about the semi-
conservative replication of DNA,
June 2019 1 4 DNA Replication
including enzyme involvement and
experimental evidence.
Questions about genetically
Modified Silk modified silkworms producing
June 2019 1 8
Proteins modified silk, involving synthetic
amino acids and protein synthesis.
Questions on the genetics of taste
Genetics and Taste
June 2021 1 4 perception, specifically the ability to
Perception
taste phenylthiocarbamide (PTC).
Questions related to cystic fibrosis,
June 2021 1 5 Cystic Fibrosis including how mutations in the
CFTR gene lead to the disease.
Questions about lifestyle risk
Lifestyle Diseases factors, their role in causing
June 2021 1 7
and Mutations mutations, and the development of
diseases like cancer.
Questions about the structure of
Cell Membrane the cell membrane and how it
June 2021 1 8
Structure affects the properties and functions
of the cell.
Questions on the enzyme pectinase
Pectinase Enzyme
June 2022 1 3 and its role in breaking down
Activity
pectin.
Questions about the structure and
Cell Membrane
June 2022 1 7 properties of cell membrane
Components
components.
Calculation and discussion of
Mutations and
June 2022 1 8 mutations in cancer and genetic
Genetic Disorders
disorders like PKU.
Drawing a genetic diagram for
October 2019 1 2 Rabbit Fur Genetics
heterozygous rabbits' offspring.
Completing a table about blood
October 2019 1 3 Haemophilia A clotting components and explaining
inheritance in haemophilia A.
Determining the sequence of amino
DNA Replication
October 2019 1 6 acids coded by a length of DNA and
Errors
explaining mutation effects.
Question
Month Year Unit Question Theme Description of the Question
Number
, Compares eukaryotic and
Cell Structure
October 2019 2 3 prokaryotic cells, focusing on their
Comparison
common features and differences.
Discusses the interaction between
Rabbit Genotype
October 2019 2 8 genes and the environment in
and Phenotype
determining the fur color of rabbits.
Bengal Tiger Analysis of Bengal tiger coat color
October 2020 1 2
Genetics genetics using a pedigree diagram.
Questions on DNA structure,
DNA Structure and
October 2020 1 4 bonding, and replication based on
Replication
Meselson and Stahl's experiment.
Understanding the genetic code in
Genetic Code and
October 2020 1 6 DNA and the effects of substitution
Mutations
mutations.
Questions about osmosis in plant
Plant Osmosis and cells, changes in mass in salt
October 2020 3 1
Water Potential solutions, and determining water
potential.
Questions about the nature of
Mutations and
October 2021 1 1 mutations and their types, and
Cancer
analysis of cancer incidence data.
Discussing the implications of
Genetic Screening
October 2021 1 5 genetic screening for aneuploidy in
for Aneuploidy
embryos.
Understanding a rare genetic
Acute Hepatic
October 2021 1 6 disorder and the impact of a
Porphyria
specific drug treatment.
Genetics question involving the
Codominance in
October 2021 1 8 concept of codominance in chicken
Chickens
feather color.
Protein Content Testing and comparing protein
October 2021 3 1
Analysis content in various foods.
Exploring the structure of a
Phospholipid phospholipid and how nonpolar
October 2022 1 1
Structure molecules move through cell
membranes.
Exploring the structure of DNA
DNA Structure and bases, calculating base pair mass in
October 2022 1 8
Replication E. coli, and understanding DNA
replication theories.
Question
Month Year Unit Question Theme Description of the Question
Number
1) International A Level Syllabus 2018
Question
Month Year Unit Question Theme Description of the Question
Number
DNA and RNA Comparison of structures of DNA
January 2019 1 3
Structures and RNA.
Membrane Study of membrane permeability
January 2019 1 5
Permeability and effects of cholesterol.
Analyzing the components found in
Polynucleotide
January 2020 1 1 DNA and mRNA using a Venn
Structure
diagram.
Investigating the function of the
Paramecium and
January 2020 1 5 contractile vacuole in paramecia in
Contractile Vacuole
different solutions.
Cystic Fibrosis Cystic fibrosis, its effects on trachea
January 2020 1 8
Analysis structure, and trends in prevalence.
Concept of polygenic inheritance,
Polygenic
January 2020 2 3 height prediction based on parental
Inheritance
heights
Components of polynucleotides,
January 2021 1 1 DNA and RNA mononucleotide structure,
complementary base pairing
Gene definition, mutations causing
January 2022 1 4 Cystic Fibrosis
cystic fibrosis, and carrier screening
Sickle cell disease mutation, p50
January 2022 1 8 Sickle Cell Disease value calculation, lifespan of red
blood cells in sickle cell disease
mRNA Vaccine Understanding mRNA vaccine and
January 2022 2 3
Mechanism its cellular interaction.
Polygenic Explaining variation in skin color
January 2022 2 6
Inheritance due to genetics.
Water Potential in Experimenting with water potential
January 2022 3 3
Carrots using carrot cylinders.
The use of nuclear DNA and
DNA Analysis in
mitochondrial DNA in distinguishing
January 2022 4 5 Species
bird species, and the application of
Identification
PCR in DNA amplification.
Questions on DNA base sequences,
DNA and Protein amino acids, and protein synthesis,
June 2019 1 3
Synthesis including calculating and explaining
genetic codes.
, Question
Month Year Unit Question Theme Description of the Question
Number
Questions about the semi-
conservative replication of DNA,
June 2019 1 4 DNA Replication
including enzyme involvement and
experimental evidence.
Questions about genetically
Modified Silk modified silkworms producing
June 2019 1 8
Proteins modified silk, involving synthetic
amino acids and protein synthesis.
Questions on the genetics of taste
Genetics and Taste
June 2021 1 4 perception, specifically the ability to
Perception
taste phenylthiocarbamide (PTC).
Questions related to cystic fibrosis,
June 2021 1 5 Cystic Fibrosis including how mutations in the
CFTR gene lead to the disease.
Questions about lifestyle risk
Lifestyle Diseases factors, their role in causing
June 2021 1 7
and Mutations mutations, and the development of
diseases like cancer.
Questions about the structure of
Cell Membrane the cell membrane and how it
June 2021 1 8
Structure affects the properties and functions
of the cell.
Questions on the enzyme pectinase
Pectinase Enzyme
June 2022 1 3 and its role in breaking down
Activity
pectin.
Questions about the structure and
Cell Membrane
June 2022 1 7 properties of cell membrane
Components
components.
Calculation and discussion of
Mutations and
June 2022 1 8 mutations in cancer and genetic
Genetic Disorders
disorders like PKU.
Drawing a genetic diagram for
October 2019 1 2 Rabbit Fur Genetics
heterozygous rabbits' offspring.
Completing a table about blood
October 2019 1 3 Haemophilia A clotting components and explaining
inheritance in haemophilia A.
Determining the sequence of amino
DNA Replication
October 2019 1 6 acids coded by a length of DNA and
Errors
explaining mutation effects.
Question
Month Year Unit Question Theme Description of the Question
Number
, Compares eukaryotic and
Cell Structure
October 2019 2 3 prokaryotic cells, focusing on their
Comparison
common features and differences.
Discusses the interaction between
Rabbit Genotype
October 2019 2 8 genes and the environment in
and Phenotype
determining the fur color of rabbits.
Bengal Tiger Analysis of Bengal tiger coat color
October 2020 1 2
Genetics genetics using a pedigree diagram.
Questions on DNA structure,
DNA Structure and
October 2020 1 4 bonding, and replication based on
Replication
Meselson and Stahl's experiment.
Understanding the genetic code in
Genetic Code and
October 2020 1 6 DNA and the effects of substitution
Mutations
mutations.
Questions about osmosis in plant
Plant Osmosis and cells, changes in mass in salt
October 2020 3 1
Water Potential solutions, and determining water
potential.
Questions about the nature of
Mutations and
October 2021 1 1 mutations and their types, and
Cancer
analysis of cancer incidence data.
Discussing the implications of
Genetic Screening
October 2021 1 5 genetic screening for aneuploidy in
for Aneuploidy
embryos.
Understanding a rare genetic
Acute Hepatic
October 2021 1 6 disorder and the impact of a
Porphyria
specific drug treatment.
Genetics question involving the
Codominance in
October 2021 1 8 concept of codominance in chicken
Chickens
feather color.
Protein Content Testing and comparing protein
October 2021 3 1
Analysis content in various foods.
Exploring the structure of a
Phospholipid phospholipid and how nonpolar
October 2022 1 1
Structure molecules move through cell
membranes.
Exploring the structure of DNA
DNA Structure and bases, calculating base pair mass in
October 2022 1 8
Replication E. coli, and understanding DNA
replication theories.
Question
Month Year Unit Question Theme Description of the Question
Number
