Pathophysiology: The Biologic Basis for Disease in Adults and Children: Chapter 10: Infection

Pathophysiology: The Biologic Basis for Disease
in Adults and Children: Chapter 10: Infection
Normal microbiome

- ✔️- resident microorganisms found in the human body



Opportunistic microorganisms

- ✔️- normally do not cause disease, but seize opportunity to do so when a
person's defensive systems are weakened or depressed



True pathogens

- ✔️- circumvent an individual's defenses and directly cause infection



Infectious Process/Stages of Microorganisms - ✔️-

1. colonization

2. invasion

3. multiplication

4. spread



Clinical Infectious Disease Stages of Humans - ✔️-

1. incubation period

2. prodromal stage

3. invasion period

4. convalescence

, Pathophysiology: The Biologic Basis for Disease
in Adults and Children: Chapter 10: Infection


Fever

- ✔️- body temperature regulated at higher level than normal, produced by
pyrogens



Exogenous pyrogens

- ✔️- derived from outside the host



Endogenous pyrogens

- ✔️- produced by individual



Factors influencing the capacity of a pathogen to cause disease - ✔️

1. communicability
2. -immunogenicity
3. -infectivity
4. -mechanism of action
5. -pathogenicity
6. -portal of entry
7. -toxigenicity
8. -virulence