Test Bank for Clinical Immunology and Serology
a Laboratory Perspective 4th Edition By Christine
Dorresteyn Stevens Linda E. miller Chapter 1-24
Latest Guide
1). The germinal centers found in the cortical region of lymph nodes and the peripheral region
of splenic periarteriolar lymphatic tissue:
Ans: contains large populations of B lymphocytes and plasma cells
2). Balance between th1 and th2 cell activation determines outcome of intracellular
infections. thus, in case of mycobacterium leprae infection:
Ans: tuberculoid leprosy will occur in patients with a prominent TH1 response
3). The initiation of t cell responses requires multiple receptors on the t cells recognizing
ligands on apcs. the mhc molecule located around the peptide-binding cleft is recognized
by the:
Ans: CD4 or CD8 molecules
4). The edema occurring in the inflammatory process is the result of all the following factors
except:
Ans: neural impulse by the sympathetic system and vasoconstriction
5). Toll-like receptors (tlr):
Ans: recognize pathogen-associated molecular patterns (PAMPs) on selective
microorganisms
6). The initiation of t cell responses requires multiple receptors on the t cells recognizing
ligands on apcs. the t cell receptor transduction molecule(s) is(are) conducted by:
Ans: CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ?
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, 7).
Ans: thymus
8). Immediate activation of the b lymphocytes following contact with the antigen involves all
of the following molecules except:
Ans: MHC class II molecules
9). Immunologic memory refers to:
Ans: changes in adaptive immune responses with subsequent encounters with
antigen
10). Both, naive mature effector t lymphocytes migrate differently in their lives. naive t cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (hevs)?
Ans: L-selectin
11). The main consequences of complement activation are all of the following except:
Ans: producing 2nd signal for macrophage activation
12). 'langerhans cells' which play a role in the immune system are:
Ans: dendritic cells located mainly in the epidermis
13). All of the following cells results in the germinal center reaction of the follicles (b
lymphocyte zone) except:
Ans: short-lived plasma cells
14). The antigen recognition on the t cells is mediated by:
Ans: the Variable (v) regions of α and β chains
15). The t-cell receptor:
Ans: recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is correct?
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, 16).
Ans: Clones of lymphocytes specific for antigens develop prior to exposure to the
antigens
17). Which of the following best describes the t-dependent antibody response?
Ans: IT is the response of follicular B lymphocytes to a protein antigen and
characterized by isotope-switched, high affinity antibodies; memory B cells, long lived
plasma cells
18). Mhc class ii molecules contain:
Ans: One α chain and one β chain
19). The inflammatory cytokines will cause langerhans cells in the epidermis to perform all of
the following except:
Ans: antigen presentation to the T cells in the follicles of the lymph nodes
20). The phases and order of the specific or acquired immune responses are:
Ans: recognition phase; activation phase; effector phase; homeostasis phase;
memory phase
21). A naive cd4+ t cell may differentiate into subsets that produce different cytokines that
recruit and activate different cell types. the ifn-γ is produced mainly by:
Ans: CD4+ T cell TH1 subset
22). Th1 subset effector cells that aid in cell mediated immune response activate the
macrophage and b lymphocytes by:
Ans: CD40L-CD40 interaction and IFN-γ
23). The diversity of antigen receptors produced by the use of different combinations of v, d,
and j gene segments in different clones of lymphocytes is the result of:
Ans: both combinatorial diversity and junctional diversity
24). All of the following statements about the b-cell antigen receptor are true except:
PaperStoc.com Page 3 of 25
a Laboratory Perspective 4th Edition By Christine
Dorresteyn Stevens Linda E. miller Chapter 1-24
Latest Guide
1). The germinal centers found in the cortical region of lymph nodes and the peripheral region
of splenic periarteriolar lymphatic tissue:
Ans: contains large populations of B lymphocytes and plasma cells
2). Balance between th1 and th2 cell activation determines outcome of intracellular
infections. thus, in case of mycobacterium leprae infection:
Ans: tuberculoid leprosy will occur in patients with a prominent TH1 response
3). The initiation of t cell responses requires multiple receptors on the t cells recognizing
ligands on apcs. the mhc molecule located around the peptide-binding cleft is recognized
by the:
Ans: CD4 or CD8 molecules
4). The edema occurring in the inflammatory process is the result of all the following factors
except:
Ans: neural impulse by the sympathetic system and vasoconstriction
5). Toll-like receptors (tlr):
Ans: recognize pathogen-associated molecular patterns (PAMPs) on selective
microorganisms
6). The initiation of t cell responses requires multiple receptors on the t cells recognizing
ligands on apcs. the t cell receptor transduction molecule(s) is(are) conducted by:
Ans: CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ?
PaperStoc.com Page 1 of 25
, 7).
Ans: thymus
8). Immediate activation of the b lymphocytes following contact with the antigen involves all
of the following molecules except:
Ans: MHC class II molecules
9). Immunologic memory refers to:
Ans: changes in adaptive immune responses with subsequent encounters with
antigen
10). Both, naive mature effector t lymphocytes migrate differently in their lives. naive t cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (hevs)?
Ans: L-selectin
11). The main consequences of complement activation are all of the following except:
Ans: producing 2nd signal for macrophage activation
12). 'langerhans cells' which play a role in the immune system are:
Ans: dendritic cells located mainly in the epidermis
13). All of the following cells results in the germinal center reaction of the follicles (b
lymphocyte zone) except:
Ans: short-lived plasma cells
14). The antigen recognition on the t cells is mediated by:
Ans: the Variable (v) regions of α and β chains
15). The t-cell receptor:
Ans: recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is correct?
PaperStoc.com Page 2 of 25
, 16).
Ans: Clones of lymphocytes specific for antigens develop prior to exposure to the
antigens
17). Which of the following best describes the t-dependent antibody response?
Ans: IT is the response of follicular B lymphocytes to a protein antigen and
characterized by isotope-switched, high affinity antibodies; memory B cells, long lived
plasma cells
18). Mhc class ii molecules contain:
Ans: One α chain and one β chain
19). The inflammatory cytokines will cause langerhans cells in the epidermis to perform all of
the following except:
Ans: antigen presentation to the T cells in the follicles of the lymph nodes
20). The phases and order of the specific or acquired immune responses are:
Ans: recognition phase; activation phase; effector phase; homeostasis phase;
memory phase
21). A naive cd4+ t cell may differentiate into subsets that produce different cytokines that
recruit and activate different cell types. the ifn-γ is produced mainly by:
Ans: CD4+ T cell TH1 subset
22). Th1 subset effector cells that aid in cell mediated immune response activate the
macrophage and b lymphocytes by:
Ans: CD40L-CD40 interaction and IFN-γ
23). The diversity of antigen receptors produced by the use of different combinations of v, d,
and j gene segments in different clones of lymphocytes is the result of:
Ans: both combinatorial diversity and junctional diversity
24). All of the following statements about the b-cell antigen receptor are true except:
PaperStoc.com Page 3 of 25
