NURS 615 exam 3 - Maryville.

corticosteroid drugs - Correct Answer prednisone, methylprednisolone, dexamethasone, topical such as hydrocortisone, and then joint injections for pain MOA of corticosteroids drugs - Correct Answer drugs that suppress inflammation by mimicking glucocorticoid hormones Inhibit interleikin one, tumor necrosis factor and other cytokines, impairs phagocytosis, impairs lymphocytes, and inhibits tissue repair indications for cortocosteriod use - Correct Answer Allergy or hypersensitivity, respiratory, shock, rheumatology, neurology, hepatic, neoplastic... basicly every organ is covered if there is an issue. withdrawal from corticorsteriod symptoms - Correct Answer malaise, myalgia, headache, nausea, fevers, hypotension and relapse of symptoms (pain, inflammation, ashtma) what must you do with corticosteriods to prevent withdrawal - Correct Answer Must taper them down, you can have possible adrenal crisis if you do not. corticosteriod considerations - Correct Answer suppression patients response to infections- no live viral vaccines, and have increased susceptibility to disease. If used over 6 months: Increase blood glucose, impair immune function (get vaccines) , impair wound healing, GI complaints (report black tarry stools) , osteoporosis (decreases calcium), anxiety/insomnia, sodium & fluid retention 9monitor weight and fluid retention) If on 1gram or more also prescribe PPI (omeprazole) to prevent PUD contraindicated with active infection and hypersensitivity What are the adverse effects of corticosteroids if administered for six months or more? - Correct Answer The main thing you want to worry about is osteoporosis It can also worsen diabetic control Patients should report any tarry black stools or abdominal pain. NSAIDS - Correct Answer nonsteroidal anti-inflammatory drugs Ibprofen, aspirin, torsdol, naproxin, Mobic Arachidonic Acid Cascade - Correct Answer Cell membrane ► Arachinidonic acid ► Cycloxygenerase (COX)► prostaglandin's Or Cell membrane ► Arachinidonic acid ► Lipoxygenase► Leukotrines NSAID mechanism of action - Correct Answer • NSAIDs inhibit the enzymes COX I and II • Results in reduction in formation of prostaglandin precursors and thromboxanes from arachidonic acid COX1- ibuprofen, naproxen, aspirin, when this is inhibited you are also inhibiting the prostaglandins that protect the stomach COX2 - celebrex more stomach proctective Drug interactions with NSAIDS - Correct Answer Pretty much anything that is highly protien bound. Do not give together with ACE inhibitors - counteracts antihypertensive effect BetaBlockers - counteracts