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Class notes BT3401 (BT3401)

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Lecture notes of 6 pages for the course BT3401 at Anna University (Nice)

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DNA- Structure and function of Deoxyribonucleic Acid
(DNA)


Let's delve into the structure and function of DNA. DNA, short for
Deoxyribonucleic Acid, is a molecule found inside the nucleus of a
cell. Its primary role is to store and code the genetic information
of the body. During most of the cell's life cycle, the DNA is coiled
up inside the nucleus like a noodle. However, when the cell
replicates, the DNA is arranged into structures called
chromosomes. These chromosomes help maintain the stability of
the DNA during cell replication.

Most people are familiar with the double helix model of DNA,
which demonstrates that DNA is a polymer. To understand DNA
better, it's important to understand the definition of a polymer. A
polymer is a molecule consisting of many repeating units, known
as monomers. For example, the simple polymer starch is made up
of repeating glucose monomers, joined together by glucosidic
bonds.

In a similar way, DNA is also a polymer, but in this case, the
monomers that form DNA are known as nucleotides. A nucleotide
has three important groups: phosphate, sugar, and nitrogenous
base. The sugar in DNA is deoxyribose, and the nitrogenous
bases are adenine, guanine, cytosine, and thymine. These
nucleotides are joined together by phosphodiester bonds to form
the polymer that is DNA.

Nucleic Acids: Double-stranded Molecules with Important Genetic Information

Difference Between DNA and RNA: Form, Functions, and Molecular Structure

DNA (deoxyribonucleic acid) is a double-stranded molecule, while RNA
(ribonucleic acid) is typically single-stranded

DNA stores genetic information in the body, while RNA plays a role in protein
synthesis

DNA has deoxyribose sugar and thymine base, while RNA has ribose sugar
and uracil base

, DNA has a right-handed helix known as the B-form, while RNA can have an A-
form or a B-form helix

Purine and Pyrimidine: Categories of Nucleotide Bases in Nucleic Acids

Purines have a double-ring structure, with adenine (A) and guanine (G) being
the two purines found in nucleic acids

Pyrimidines have a single-ring structure, with thymine (T) and cytosine ©
found in DNA, and uracil (U) and cytosine © found in RNA.

Nucleoside and Nucleotide: Components of Nucleic Acids and Their
Nomenclature

Nucleosides are composed of a sugar and a base, i.e. nucleoside = sugar +
base

Nucleotides are composed of a nucleoside and one or more phosphate
groups, i.e. nucleotide = nucleoside + phosphate(s)

Nucleotides can be linked together via phosphodiester bonds between the
phosphate of one nucleotide and the sugar of another, creating a nucleic
acid polymer.

DNA and RNA Strands: Anti-Parallel Connectivity and Hydrogen Bonds

In DNA, the two strands are anti-parallel, meaning they run in opposite
directions.

DNA strands are held together by hydrogen bonds between bases: Adenine
(A) with Thymine (T) and Guanine (G) with Cytosine(C)

In RNA, the single strand can also form secondary structure through base-
pairing between complementary sequences, forming hydrogen bonds.

Note: The above outlines the main differences between DNA and RNA, the
purines and pyrimidines, nucleosides and nucleotides, and the anti-parallel
connectivity and hydrogen bonds of DNA and RNA strands. This information
provides an overview of the crucial concepts related to nucleic acids.

Difference Between DNA and RNA: Form, Functions, and Molecular Structure

Nucleic acids are crucial molecules in all living organisms, carrying important
genetic information. There are two main types of nucleic acids: DNA and
RNA. While both have similar structures and functions, there are key
differences between them.

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