Pharmacology III Exam With 100% Correct Answers | Already Passed| Graded A+

The major determinant of the rate of angiotensin II production is the amount of . . . - Renin released by the kidney The macula densa senses . . . - The sodium content leaving the loop of Henle What causes the macula densa to inhibit renin release? - 1. Blood pressure is high 2. GFR is high 3. Increase in NaCl flux What serves as the signal to stimulate renin release? - Prostaglandins Beta-Adrenergic Receptor Pathway - Norepinephrine from postganglionic sympathetic nerve terminals leads to activation of beta-1 adrenergic receptors causing enhanced renin secretion Describe the short-loop negative feedback of the RAS system - INCREASES in renin enhance ANG II formation which then stimulate angiotensin subtype 1 receptors (AT1) on juxtaglomerular cells to INHIBIT renin release Bradykinin - A potent vasodilator What inactivates bradykinin? - ACE What is the preferred substrate for ACE-2? - Angiotensin II (1-8)