2024 PEBC Questions and Accurate Answers.

Time it takes for amount of drug to fall to half of its value, constant in first order kinetics (majority of drugs) correct answers Half-life (T1/2) Inducers of Cytochrome P450 (CYP450) (4) correct answers Barbiturates Phenytoin Carbamazepine Rifampin Inhibitors of CYP450 correct answers Cimetidine Ketoconazole Erythromycin Isoniazid Grapefruit Their MOA utilizes intracellular receptors: correct answers Thyroid and steroid hormones This compound's MOA utilizes transmembrane receptors: correct answers Insulin Antidote used for organophosphate/anticholinesterase correct answers Atropine, pralidoxime (2-PAM) Antidote used for acetaminophen (APAP) toxicity correct answers N-acetylcysteine Antidote used for heparin toxicity correct answers Protamine Sulfate Antidote used for warfarin toxicity correct answers Vitamin K and Fresh frozen plasma (FFP) Antidote for tissue plasminogen activator (t-PA), streptokinase correct answers Aminocaproic acid Antidote used for opioid toxicity correct answers Naloxone (IV), naltrexone (PO) Antidote used for benzodiazepine toxicity correct answers Flumazenil Interaction with this drug requires dose reduction of 6-MP(6-mercaptopurine) correct answers Allopurinol May protect against doxorubicin cardio-toxicity by chelating iron correct answers Dexrazoxane Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis correct answers Bleomycin Binds tubulin and prevents the disassembly of microtubules during the M phase of the cell cycle inducing mitotic arrest correct answers Paclitaxel (taxol)