NUR GENOMIC MUTATIONS PREDICTOR QUESTIONS AND 100% CORRECT ANSWERS A+ GRADED

1- is permenant change in nucleotide sequence. a. Mutation . b. DNA repair c. Translation d. Staining 2- Which of the following is not correct for mutation a. Mutation can be chromosomal or DNA levels. b. Chromosomal mutation is Gross lesion less than 8%. c. DNA mutation is Gross lesion less than 8%. d. DNA mutation is micro-lesion more than 92%. 3- Causes of mutation …………….. a. Exposure to mutagenic agent. b. Errors through DNA replication and repair. c. DNA repair. d. Both a and b. 4- Structural chromosomal abnormalities not included……………… a. Translocation, deletion and insertion. b. Inversions and ring formation. c. Aneuploidy and polyploidy. d. Both a and b. 5- Numerical chromosomal abnormalities not includes………………. a. Aneuploidy. b. Polyploidy. c. Translocation. d. Both a and b. 6- can not be transmitted to offspring but can be to the future generations. a. Somatic call mutation. b. Germ line call mutation. c. Both a and b. d. Non a nor b. 7- ………………… is common variation greater than 1% with no change in function or has small effect. a. Mutation. b. Polymorphism. c. Both a and b. d. Non a nor b. 8- can be classified according to the specific molecular changes at the DNA level. a. Fixed mutation. b. Dynamic mutation. c. Unstable mutation. d. Non of the above. 9- Fixed mutation includes ……………. a. Substitutions and insertions. b. Deletion and duplication. c. Both a and b. d. Non of the above. 10 is the replacement of a single nucleotide by anther. a. Substitution mutation. b. Insertion mutation. c. Deletion mutation. d. Duplication mutation. 11- Transition and transversion mutation are types of……….. a. Substitution mutation. b. Insertion mutation. c. Deletion mutation. d. Duplication mutation. 12- Transversion is …………….. a. Substitution of a pyrimidine base by a pyrimidine. b. Substitution of a pyrimidine base by a purine and vice versa. c. Substitution of a Purine base by a purine base. d. Non of the above. 13 Involved the loss of one or more nucleotides. a. Substitution mutation. b. Insertion mutation. c. Deletion mutation. d. Duplication mutation. 14 leads to disturb the reading frame. a. Insertion mutation. b. Deletion mutation. c. Both a and b. d. Non a nor b. 15 Addition of one or more nucleotide into a gene. a. Substitution mutation. b. Insertion mutation. c. Deletion mutation. d. Duplication mutation. 16 consists of triplet repeat sequence which is affected person occurs in increase copy number which compared to general population. a. Dynamic mutation. b. Fixed point mutation. c. Stable mutation. d. Duplication mutation. 17 is single base pair substitution result coding for different amino acids and synthesis of altered protein. a. Missense mutation. b. Non sense mutation. c. Frame shift mutation. d. Non of the above. 18- ……………………. Substitution of base pair which leads to the generation of one of the stop codon. a. Non sense mutation. b. Miss ends mutation. c. Frame shift mutation. d. Non of the above. 19 reduce the biological activity. a. Non sense mutation. b. Miss ends mutation. c. Frame shift mutation. d. Non of the above. 20 involves the insertion or deletion of nucleotides which are not a multiple of three. a. Non sense mutation. b. Miss ends mutation. c. Frame shift mutation. d. Non of the above. 21 responsible of some types of familial hyper cholesterolemia. a. Non sense mutation. b. Miss ends mutation. c. Frame shift mutation. d. Non of the above. Question Mutagens 1- mutation are referred to as spontaneous mutations through DNA replication. a. Natural. b. Artificial. c. Chemical. d. Physical. 2- Chemical, physical and biological agents increase rate of mutation are ……. a. Inherited agents of mutation. b. Induced agents of mutation. c. Natural agents of mutation. d. None of the above. 3- Mutagenic In food contribute to 35% of cancer agent. a. Natural. b. Artificial. c. Chemical. d. Physical. 4- caused fragmentation of chromosomes. a. Clastogene b. Mutagene. c. Oncogene. d. Teratogene. 5- result of abnormalities in natural mutagenesis. a. Clastogene. b. Mutagenesis. c. Oncogene. d. Tertogene. 6- Which of the following is the cause of spontaneous mutation……….. a. Errors in DNA replication. b. Faulty of DAN repair c. Naturally mutagenesis. d. All of the above. 7- Ionizing and non ionizing radiation are………………….. mutagenic agents. a. Natural. b. Artificial. c. Chemical. d. Physical. Question of DNA repair 1- DAN repair mechanisms to ………… a. Correct DNA damage. b. Prevent environmental mutagenesis. c. Prevent base misincorporation. d. All of the above. 2- DAN repair mechanisms start by the action of exonuclease which cleavage the damage strand at two sites…………. a. Excision repair. b. Mismatch repair. c. Recombination repair. d. Double strand repair. 3- Mechanisms of DNA repair………….. a. Excision repair and Mismatch repair. b. Recombination repair. c. Double strand repair. d. All of the above. 4- Microsatellite instability occures due to failure of……… a. Mismatch repair. b. Recombination repair. c. Double strand repair. d. Excision repair.