7- Pharmacological Management of
Parkinson’s Disease
A- Intro • tremor at rest
• rigidity
• bradykinesia
1- Symptoms:
• postural instability (instability of balance)
2- Histopathology: degeneration of dopaminergic neurons in supstantia nigra + neurons in
the autonomic ganglia, basal ganglia, spinal cord and neocortex.
3- Etio: chronic exposure to pesticides, heavy metals, rural water and drinking well water //
an inverse correlation between cigarette an caffeine consumption and PD development,
Parkinson’s Disease
A- Intro • tremor at rest
• rigidity
• bradykinesia
1- Symptoms:
• postural instability (instability of balance)
2- Histopathology: degeneration of dopaminergic neurons in supstantia nigra + neurons in
the autonomic ganglia, basal ganglia, spinal cord and neocortex.
3- Etio: chronic exposure to pesticides, heavy metals, rural water and drinking well water //
an inverse correlation between cigarette an caffeine consumption and PD development,
