, eleventh edition
Human Genetics
Concepts and Applications
Ricki Lewis
Genetic Counselor
CareNet Medical Group
Schenectady, New York
Adjunct Assistant Professor of
Medical Education
Alden March Bioethics Institute
Albany Medical College
Writer, Medscape Medical News
Blogger, Public Library of Science
lew25367_fm_i-xx.indd i 2
, HUMAN GENETICS: CONCEPTS AND APPLICATIONS, ELEVENTH EDITION
Published by McGraw-Hill Education, 2 Penn Plaza, New York, NY 10121. Copyright © 2015 by McGraw-Hill
Education. All rights reserved. Printed in the United States of America. Previous editions © 2012, 2010, and
2008. No part of this publication may be reproduced or distributed in any form or by any means, or stored in
a database or retrieval system, without the prior written consent of McGraw-Hill Education, including, but not
limited to, in any network or other electronic storage or transmission, or broadcast for distance learning.
Some ancillaries, including electronic and print components, may not be available to customers outside the
United States.
This book is printed on acid-free paper.
1 2 3 4 5 6 7 8 9 0 DOW/DOW 1 0 9 8 7 6 5 4
ISBN 978-0-07-352536-5
MHID 0-07-352536-7
Senior Vice President, Products & Markets: Kurt L. Strand
Vice President, General Manager, Products & Markets: Marty Lange
Vice President, Content Design & Delivery: Kimberly Meriwether David
Managing Director: Michael Hackett
Brand Manager: Rebecca Olson
Director, Product Development: Rose Koos
Product Developer: ansrsource
Marketing Manager: Patrick Reidy
Director, Content Design & Delivery: Linda Avenarius
Program Manager: Angela R. Fitzpatrick
Content Project Managers: Sheila M. Frank, Christina Nelson
Buyer: Sandy Ludovissy
Design: Tara McDermott
Content Licensing Specialists: Carrie Burger, ansrsource and Sheri Gilbert
Cover Images: Paul Burns/Getty Images/RF (albino man); Steve Mason/Getty Images/RF (blonde girl in water);
Getty Images/RF (girl with milk mustache); Courtesy, Lori Sames. Photo by Dr. Wendy Josephs (girl with dog);
© Stockbyte/Veer/RF (little blonde boy); Tom Grill/Corbis/RF (toddler playing with DNA model)
Compositor: Laserwords Private Limited
Typeface: 10/12 Times Roman LT Std
Printer: R. R. Donnelley
All credits appearing on page or at the end of the book are considered to be an extension of the copyright page.
Library of Congress Cataloging-in-Publication Data
Lewis, Ricki.
Human genetics : concepts and applications/Ricki Lewis, Genetic Counselor, CareNet Medical Group, Sche-
nectady, New York, Adjunct Assistant Professor of medical education, Alden March Bioethics Institute, Albany
Medical College, writer, Medscape Medical News, blogger, Public Library of Science.—Eleventh edition.
pages cm
ISBN 978-0-07-352536-5 (alk. paper)
1. Human genetics—Textbooks. I. Title.
QH431.L41855 2015
599.93’5—dc23
2014020906
The Internet addresses listed in the text were accurate at the time of publication. The inclusion of a website does
not indicate an endorsement by the authors or McGraw-Hill Education, and McGraw-Hill Education does not
guarantee the accuracy of the information presented at these sites.
www.mhhe.com
lew25367_fm_i-xx.indd ii 2
, About the Author
Ricki Lewis has built an eclectic career in communicating the excitement of genetics
and genomics. She earned her Ph.D. in genetics in 1980 from Indiana University.
It was the dawn of the modern biotechnology era, which Ricki chronicled in many
magazines and journals. She published one of the first articles on DNA fingerprinting
in Discover magazine in 1988, and a decade later one of the first articles on human
stem cells in The Scientist.
Ricki has taught a variety of life science courses at Miami University, the University
at Albany, Empire State College, and community colleges. She has authored or
co-authored several university-level textbooks and is the author of The Forever Fix:
Gene Therapy and the Boy Who Saved It, as well as an essay collection and a novel .
Ricki has been a genetic counselor for a private medical practice since 1984 and is
a frequent public speaker. Since 2012, Ricki has written hundreds of news stories
for Medscape Medical News, articles for Scientific American and for several genetic
disease organizations, and originated and writes the popular weekly DNA Science
blog at Public Library of Science.
Ricki teaches an online course on “Genethics” for the Alden March Bioethics Institute
of Albany Medical College. She lives in upstate New York and sometimes Martha’s
Vineyard, with husband Larry and several felines. Contact Ricki at rickilewis54@gmail
com, or join the discussion on DNA Science at http://blogs.plos.org/dnascience/.
Dedicated to the
families who live with genetic diseases, the
health care providers who help them, and
the researchers who develop new tests
and treatments.
i
lew25367_fm_i-xx.indd iii 2
Human Genetics
Concepts and Applications
Ricki Lewis
Genetic Counselor
CareNet Medical Group
Schenectady, New York
Adjunct Assistant Professor of
Medical Education
Alden March Bioethics Institute
Albany Medical College
Writer, Medscape Medical News
Blogger, Public Library of Science
lew25367_fm_i-xx.indd i 2
, HUMAN GENETICS: CONCEPTS AND APPLICATIONS, ELEVENTH EDITION
Published by McGraw-Hill Education, 2 Penn Plaza, New York, NY 10121. Copyright © 2015 by McGraw-Hill
Education. All rights reserved. Printed in the United States of America. Previous editions © 2012, 2010, and
2008. No part of this publication may be reproduced or distributed in any form or by any means, or stored in
a database or retrieval system, without the prior written consent of McGraw-Hill Education, including, but not
limited to, in any network or other electronic storage or transmission, or broadcast for distance learning.
Some ancillaries, including electronic and print components, may not be available to customers outside the
United States.
This book is printed on acid-free paper.
1 2 3 4 5 6 7 8 9 0 DOW/DOW 1 0 9 8 7 6 5 4
ISBN 978-0-07-352536-5
MHID 0-07-352536-7
Senior Vice President, Products & Markets: Kurt L. Strand
Vice President, General Manager, Products & Markets: Marty Lange
Vice President, Content Design & Delivery: Kimberly Meriwether David
Managing Director: Michael Hackett
Brand Manager: Rebecca Olson
Director, Product Development: Rose Koos
Product Developer: ansrsource
Marketing Manager: Patrick Reidy
Director, Content Design & Delivery: Linda Avenarius
Program Manager: Angela R. Fitzpatrick
Content Project Managers: Sheila M. Frank, Christina Nelson
Buyer: Sandy Ludovissy
Design: Tara McDermott
Content Licensing Specialists: Carrie Burger, ansrsource and Sheri Gilbert
Cover Images: Paul Burns/Getty Images/RF (albino man); Steve Mason/Getty Images/RF (blonde girl in water);
Getty Images/RF (girl with milk mustache); Courtesy, Lori Sames. Photo by Dr. Wendy Josephs (girl with dog);
© Stockbyte/Veer/RF (little blonde boy); Tom Grill/Corbis/RF (toddler playing with DNA model)
Compositor: Laserwords Private Limited
Typeface: 10/12 Times Roman LT Std
Printer: R. R. Donnelley
All credits appearing on page or at the end of the book are considered to be an extension of the copyright page.
Library of Congress Cataloging-in-Publication Data
Lewis, Ricki.
Human genetics : concepts and applications/Ricki Lewis, Genetic Counselor, CareNet Medical Group, Sche-
nectady, New York, Adjunct Assistant Professor of medical education, Alden March Bioethics Institute, Albany
Medical College, writer, Medscape Medical News, blogger, Public Library of Science.—Eleventh edition.
pages cm
ISBN 978-0-07-352536-5 (alk. paper)
1. Human genetics—Textbooks. I. Title.
QH431.L41855 2015
599.93’5—dc23
2014020906
The Internet addresses listed in the text were accurate at the time of publication. The inclusion of a website does
not indicate an endorsement by the authors or McGraw-Hill Education, and McGraw-Hill Education does not
guarantee the accuracy of the information presented at these sites.
www.mhhe.com
lew25367_fm_i-xx.indd ii 2
, About the Author
Ricki Lewis has built an eclectic career in communicating the excitement of genetics
and genomics. She earned her Ph.D. in genetics in 1980 from Indiana University.
It was the dawn of the modern biotechnology era, which Ricki chronicled in many
magazines and journals. She published one of the first articles on DNA fingerprinting
in Discover magazine in 1988, and a decade later one of the first articles on human
stem cells in The Scientist.
Ricki has taught a variety of life science courses at Miami University, the University
at Albany, Empire State College, and community colleges. She has authored or
co-authored several university-level textbooks and is the author of The Forever Fix:
Gene Therapy and the Boy Who Saved It, as well as an essay collection and a novel .
Ricki has been a genetic counselor for a private medical practice since 1984 and is
a frequent public speaker. Since 2012, Ricki has written hundreds of news stories
for Medscape Medical News, articles for Scientific American and for several genetic
disease organizations, and originated and writes the popular weekly DNA Science
blog at Public Library of Science.
Ricki teaches an online course on “Genethics” for the Alden March Bioethics Institute
of Albany Medical College. She lives in upstate New York and sometimes Martha’s
Vineyard, with husband Larry and several felines. Contact Ricki at rickilewis54@gmail
com, or join the discussion on DNA Science at http://blogs.plos.org/dnascience/.
Dedicated to the
families who live with genetic diseases, the
health care providers who help them, and
the researchers who develop new tests
and treatments.
i
lew25367_fm_i-xx.indd iii 2
