Rh Blood Group System SOLUTIONS 2024

Rh Antigens - Correct Answer Non glycosilated protein Transmembrane polypeptide Integral part of the RBC membrane Only small loops of the Rh proteins are exposed on the surface of the red cell. Levine and Stetson - Correct Answer HTR in obstetric px An Ab was isolated from the px that reacted both at 37C and 20C with the donor's RBCs 1939 Landsteiner and Weiner - Correct Answer Discovered in 1940 that, Ab made by guinea pigs and rabbits when transfused with Rhesus monkey red cells. This Ab agglutinated 85% of human RBCs and was named "Rh" Fisher-race - Correct Answer DCE terminology Three closely linked sets of alleles Set of Rh genes inherited from each parent No d antigen has been found (an amorph or a silent allele) Codominant - so each inherited gene expresses its corresponding antigen on the red cells. Weiner: The Rh-hr terminology - Correct Answer Nomenclature Single gene at the Rh locus produces an agglutinogen. Blood factors: Rho, rh', rh'', hr', hr'' Rosenfield - Correct Answer The alphanumeric terminology Has no genetic basis A minus sign preceding a number designates absence of the antigen. Disadvantage: similar nomenclature for other blood groups. Advantage: RBC phenotype is clearly described, suited for electronic data processing ISBT - Correct Answer The numeric terminology Formed the working party on terminology for Red cell surface antigens. Mandate: To establish a uniform nomenclature that is both eye and machine readable and is keeping with the genetic basis of blood groups. Chromosome 1 - Correct Answer Rh is located at what chromosome RHD and RHCE - Correct Answer The two adjacent genes for Rh protein 416 amino acids with 12 transmembrane domains. 6 extracellular loops and a cytoplasmic amino and carboxy terminus.