Rh System SOLUTIONS 2024

Is the Rh system more or less polymorphic than ABO? - Correct Answer More What are the five major antigens of Rh? - Correct Answer D, C, c, E, e What does the Fisher-Race theory state? - Correct Answer Rh is 3 separate genes closely linked CDe most common What does the Wiener theory state? - Correct Answer Rh is one gene complex with many alleles Capital "R" have D antigen Lower case "r" lack D antigen R0, R1, R2, RZ, r, r', r'', ry What is the Wiener notation for single antigens? - Correct Answer Rh0: D rh': C rh'': E hr': c hr'': e (rh= capital, hr= lower case) ( ' = C/c, '' = E/e) What do R1, R2, R0, and Rz indicate? - Correct Answer R1: DCe R2: DcE R0: Dce (neither C / E) Rz: DCE (both C & E) What do r', r'', r, and ry indicate? - Correct Answer r': dCe r'': dcE r: dce ry: dCE How many loci are in the Rh system? - Correct Answer RHD & RHCE RHD: regulates D protein RHCE: produces protein carrier for C/c,E/e antigens How do the proteins of the Rh system interact with the RBC membrane? - Correct Answer Loop back and forth through it Exterior loops serve as epitopes for antigen recognition What are the Rh proteins made of, & how was it difficult to study them? - Correct Answer Pure proteins, no carbohydrates Lack antigenicity when removed from RBC