The RH System Questions with 100% Correct Answers 2023/2024

The Rh system was indentified in 1940 by: - Correct Answer Landsteiner and Wiener after Levine and Stetson detected the antibody in 1039 It was named because Landsteiner and Wiener found that is was common to all: - Correct Answer Rhesus monkeys and 85% of humans The Rh system system is complex with more than 40 different Rh antigens - Correct Answer Rh positive and Rh negative refer to ONLY the presence or absence of the D antigen on RBCs People that are Rh ("D") negative (unlike ABO) should not have corresponding antibodies present in there serum/plasma - - Correct Answer unless they have been exposed to the "D" antigen via transfusion or pregnancy "D" and four other Rh antigens (C/c and E/e) account for the majority of Rh antibodies- - Correct Answer encountered in blood banking. The antithetical antigen for D has not been identified at this point and so when the allelic little "d" gene is expressed in literature: - Correct Answer it is primarily for convenience in explaining the topic The Rh genes are located on chromosome 1. There are 3 Rh genetic theories. - Correct Answer Tippett describles 2 closely linked loci(genes) which is accepted today. The following 2 theories were postulated before recent advances in molecular genetics but are still utilized in the lab setting. (why we study them). Fisher-Race describes 3 closely linke loci, inherited as a unit. Weiner theorized they are inherited as a single complex locus. There are 3 nomenclatures for the Rh system - Correct Answer They are Fisher-Race, Wiener, and Rosenfield (numeric). Rosenfield is not commonly used. Fisher-Race is easy beacuse the actual letters used to denote the Rh antigens are used. - Correct Answer R=D use 1, 2, z with big R r=d use y, ' , and " with little r 1=C ' =c note* little e is understood 2=E and if r has nothing-the ⁰ is " =E understood y=CE z=CE ⁰=ce