QUESTIONS AND ANSWERS
A colon cancer screening study is being conducted in Burkeshire, England.
Individuals 50 to 75 years old will be screened with the Hemoccult test. In this
test, a stool sample is tested for the presence of blood. The Hemoccult test has a
sensitivity of 70% and a specificity of 75%. If Burkeshire has a prevalence of
12/1,000 for colon cancer, what is the computed positive predictive value of the
Hemoccult test? - CORRECT ANSWER 3.3%
Primary prevention - CORRECT ANSWER Immunization, reducing exposure to a
risk factor
Secondary prevention - CORRECT ANSWER Screening for breast cancer
Tertiary prevention - CORRECT ANSWER Rehabilitation after a surgical procedure
A physical examination was used to screen for breast cancer in 2,500 women with
biopsy-proven adenocarcinoma of the breast and in 5,000 age- and race-matched
control women. Results of the physical examination were positive, meaning that a
mass was palpated in 1,800 cases and in 800 control women, all of whom showed
no evidence of cancer at biopsy. The sensitivity of the physical examination was
________ percent. - CORRECT ANSWER 72%
A program manager from an international health funding agency wants to identify
regions that would benefit from an intervention to reduce premature disability.
The program manager asks you to develop a proposal using an index that would
assist in making this decision. Which of the following would best serve this
, purpose to provide the needed information? - CORRECT ANSWER Disability-
adjusted life-years
A research study reported a weighted Kappa statistic of Kappa = 0.86 between
raters (Kappa = 0.86). The reported Kappa statistic indicates ________. - CORRECT
ANSWER
Herd Immunity - CORRECT ANSWER The resistance of a group of people to an
attack by a disease to which a large proportion of members of the group are
immune
Incubation period - CORRECT ANSWER The interval from receipt of infection to
the time of onset of clinical illness
Preclinical disease - CORRECT ANSWER Disease that is not yet clinically apparent
but will progress to clinical disease
Persistent (chronic) disease - CORRECT ANSWER Disease that persists for years
and sometimes for one's lifetime
A screening test is used in the same way in two similar populations, but the
proportion of false-positive results among those who test positive in population A
is lower than that among those who test positive in population B. The most likely
explanation for this finding is ________. - CORRECT ANSWER the prevalence of
disease is higher in population A
Age-adjusted death rates are used to: - CORRECT ANSWER Eliminate the effects
of differences in the age distributions of populations in comparing death rates