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PANDAS
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
Presentation appears like acute onset of OCD including food restriction and two or more of the
following:
anxiety
emotional lability
depression
irritability
opposition
ADHD symptoms
Academic decline
regressive bx
MSE may reveal SIB, regressive language such as "baby talk" incongruent laughter
Treat the source of the infection, immunotherapies and anti-inflammitory treatments.
Also recommend benzo or antipsychotic agent
Symptoms may reoccur
PANS
Pediatric Acute Onset Neuropsychiatric Symptoms
Associated with bacterial or viral infections such as influenza or M. Pneumonia or lyme
Symptoms are often severe and episodic
,often accompanied by Severe separation anxiety
MSE may reveal SIB, regressive language such as "baby talk" incongruent laughter
Treat the source of the infection, immunotherapies and anti-inflammitory treatments.
Also recommend benzo or antipsychotic agent
Symptoms may reoccur
ACES
Adverse Childhood Experiences
There are 10 types of childhood trauma
5 person-physical abuse, verbal abuse, sexual abuse, physical neglect, and emotional neglect
5 family related-family substance use, domestic violence, family member in jail, family with mental
illness, and divorce of parents
Each type of trauma counts as a 1 which totals the ACE score
Questions are asked in relation to prior to 18th birthday
The ACE study was large and well known and linked childhood trauma to chronic disease states and
emotional/social problems i.e as the ACE score increases so does the risk of disease states
primary prevention
Efforts to prevent an injury or illness from ever occurring.
, secondary prevention
Efforts to limit the effects of an injury or illness that you cannot completely prevent.
tertiary prevention
actions taken to contain damage once a disease or disability has progressed beyond its early stages
Brain Plasticity Theory
Changes in brain structures in children/adults effect on ability to learn and perform tasks
monoamine theory of depression
theory that depression is at least sometimes due to absolute/relative depletion of one or both
neurotransmitters (5-HT and NE) at important receptor sites in the brain
* research has shown that depression is not this straightforward
Serotonin Syndrome
With any drug that increases 5-HT (e.g., MAO inhibitors, SNRIs, TCAs) hyperthermia, confusion,
myoclonus, cardiovascular instability, flushing, diarrhea, seizures.
-Treatment: cyproheptadine (5-HT2 receptor antagonist).
Amygdala
A limbic system structure involved in memory and emotion, particularly fear, anxiety and aggression.