DOMAIN I-II - GEORGETTE (SCIENTIFIC
FOUNDATIONS/AP SKILLS) QUESTIONS AND
ANSWERS
What is the function of the Thalamus?
Sensory relay station. Smell is the only sense that by passes the thalamus. Also
emotions, memory, and affective behavior
All of the limbic structures regulate emotion and memory except for
hypothalamus
Damage to what part of the brain would result in Wernicke's Receptivee aphasia?
Temporal lobe
Irritability, hostility, depression, sleep dysregulation, loss of appetite, and loss of
libido are associated with a deficiency in which neurotransmitter?
serotonin
Facial and tongue swelling, macules, papules, "burning" confluent erythematic
rash, skin sloughing, and fever are symptoms of what condition?
SJS
Orientation, Registration, Concentration, Recall, Language are components of
what exam?
MMSE
Sudden, explosive headache in the occipital region increased BP
facial flushing, palpitations, pupillary dilation, diaphoresis, and fever are
symptoms of what condition?
Hypertensive crisis
What is the therapeutic range for lithium?
0.6-1.2
What is the gold standard for treating manic episodes?
Lithium
Which agent has antisuicidal effects in bipolar disorder?
Lithium
What is a toxic blood level of lithium?
1.5
At what blood level do you have an increased risk for toxic side effects with
lithium?
1.2
For what drug should you order thyroid panel, SCr/BUN, HCG, and
ECG (if >50 yrs) at baseline?
Lithium
Which medication is almost always the correct mood stabilizer for bipolar
disorder?
lithium
Which medication is almost never the correct mood stabilizer for bipolar
disorder?
carbamazepine
,Meperidine, decongestants, TCAs, SGA, St. John's Wort, L-tryptophan,
stimulants, sympathomimetics, and asthma medications when combined with
MAOIs cause what to happen?
Hypertensive crisis
How is a hypertensive crisis treated?
Phentolamine
Floppy baby syndrome and cleft palate are a teratogenic risk for what drug?
Benzodiazepines
What is the teratogenic risk of carbamazepine use?
Neural tube defects
What is the teratogenic risk of lithium use?
Epstein anomaly
Neural tube defects (spina bifida), atrial septal defect, cleft palate, and LT
developmental deficits are teratogenic risk of what drug?
Valproic acid
What is Pregnancy Category A?
Controlled studies show no risk
What is Pregnancy Category B?
No evidence of risk in humans
What is Pregnancy Category C?
Risk cannot be ruled out
What is Pregnancy Category D?
Positive evidence of risk
What is Pregnancy Category X?
Absolutely contraindicated
What medication has a black box warning for agranulocytosis and aplastic
anemia?
Carbamazepine
What medication has a black box warning for hepatotoxicity and pancreatitis?
Valproic cid
What medication has a black box warning for serious rash?
Lamotrigine
Which population is at greatest risk for SJS?
Asians, HLA-B 1502
Pallor, fatigue, headache, fever, nosebleeds, bleeding gums, rash
and SOB are symptoms of what condition?
aplastic anemia
If a patient is Asian and develops SJS, what is the most likely causative agent?
carbamazepine
If a patient develops SJS, but ethnicity is not given, what is the most likely
causative agent?
lamictal
What vitamin should pregnant women receiving carbamazepine for valproic acid
receive?
Folic acid (0.4 - 0.8 mg/day)
When should clozapine be discontinued?
, ANC <1,000 even if asymptomatic
At what WBC count should you discontinue clozapine?
<2000-3000
What is normal WBC count?
4,000-11,000
Sudden fever, chills, sore throat, and weakness are symptoms of what condition?
agranulocytosis
How often is ANC monitored with clozapine?
Weekly x 6 months; Biweekly x 6 months; then Monthly
Should WBC count be obtained with clozapine?
No. Just ANC
Agranulocytosis, myocarditis, and seizures are side effects of what drug?
clozapine
What antipsychotic can cause sialorrhea hypersalivation
Clozapine
What is ANC in mild neutropenia?
1,000-2,000
What is ANC in moderate neutropenia?
500-1,000
What is ANC in agranulocytosis (severe neutropenia)?
<500
How long and how often must binge eating occur for bulimia nervosa and binge
eating disorder to be diagnosed?
at least once/week x 3 months
What is the % BMI in anorexia nervosa?
<85% of expected weight
How does Binge eating disorder differ from bulimia nervosa?
No compensatory behavior purging
Amenorrhea, VS bradycardia, hypotension, hypothermia, ECG changes, yellow
skin, lanugo, peripheral edema, emaciation are physical exam findings in which
disorder?
Anorexia
Russel's sign callus on dorsum of hand from vomiting, erosion of dental enamel,
hypertrophy of salivary glands, and normal weight are physical exam findings in
what disorder?
Bulimia
Electrolytes changes hypokalemia, hypomagnesemia, hypoglycemia, hematology
changes leukopenia, anemia, thrombocytopenia, and decreased LH and FSH are
present with which disorder?
Anorexia
Electrolytes changes hypokalemia, hypomagnesemia, hyponatremia,
hypochloremia, metabolic acidosis or alkalosis, and increased serum amylase are
present in which disorder?
Bulimia
What is the pharmacologic treatment of Bulimia Nervosa?
Fluoxetine prozac
FOUNDATIONS/AP SKILLS) QUESTIONS AND
ANSWERS
What is the function of the Thalamus?
Sensory relay station. Smell is the only sense that by passes the thalamus. Also
emotions, memory, and affective behavior
All of the limbic structures regulate emotion and memory except for
hypothalamus
Damage to what part of the brain would result in Wernicke's Receptivee aphasia?
Temporal lobe
Irritability, hostility, depression, sleep dysregulation, loss of appetite, and loss of
libido are associated with a deficiency in which neurotransmitter?
serotonin
Facial and tongue swelling, macules, papules, "burning" confluent erythematic
rash, skin sloughing, and fever are symptoms of what condition?
SJS
Orientation, Registration, Concentration, Recall, Language are components of
what exam?
MMSE
Sudden, explosive headache in the occipital region increased BP
facial flushing, palpitations, pupillary dilation, diaphoresis, and fever are
symptoms of what condition?
Hypertensive crisis
What is the therapeutic range for lithium?
0.6-1.2
What is the gold standard for treating manic episodes?
Lithium
Which agent has antisuicidal effects in bipolar disorder?
Lithium
What is a toxic blood level of lithium?
1.5
At what blood level do you have an increased risk for toxic side effects with
lithium?
1.2
For what drug should you order thyroid panel, SCr/BUN, HCG, and
ECG (if >50 yrs) at baseline?
Lithium
Which medication is almost always the correct mood stabilizer for bipolar
disorder?
lithium
Which medication is almost never the correct mood stabilizer for bipolar
disorder?
carbamazepine
,Meperidine, decongestants, TCAs, SGA, St. John's Wort, L-tryptophan,
stimulants, sympathomimetics, and asthma medications when combined with
MAOIs cause what to happen?
Hypertensive crisis
How is a hypertensive crisis treated?
Phentolamine
Floppy baby syndrome and cleft palate are a teratogenic risk for what drug?
Benzodiazepines
What is the teratogenic risk of carbamazepine use?
Neural tube defects
What is the teratogenic risk of lithium use?
Epstein anomaly
Neural tube defects (spina bifida), atrial septal defect, cleft palate, and LT
developmental deficits are teratogenic risk of what drug?
Valproic acid
What is Pregnancy Category A?
Controlled studies show no risk
What is Pregnancy Category B?
No evidence of risk in humans
What is Pregnancy Category C?
Risk cannot be ruled out
What is Pregnancy Category D?
Positive evidence of risk
What is Pregnancy Category X?
Absolutely contraindicated
What medication has a black box warning for agranulocytosis and aplastic
anemia?
Carbamazepine
What medication has a black box warning for hepatotoxicity and pancreatitis?
Valproic cid
What medication has a black box warning for serious rash?
Lamotrigine
Which population is at greatest risk for SJS?
Asians, HLA-B 1502
Pallor, fatigue, headache, fever, nosebleeds, bleeding gums, rash
and SOB are symptoms of what condition?
aplastic anemia
If a patient is Asian and develops SJS, what is the most likely causative agent?
carbamazepine
If a patient develops SJS, but ethnicity is not given, what is the most likely
causative agent?
lamictal
What vitamin should pregnant women receiving carbamazepine for valproic acid
receive?
Folic acid (0.4 - 0.8 mg/day)
When should clozapine be discontinued?
, ANC <1,000 even if asymptomatic
At what WBC count should you discontinue clozapine?
<2000-3000
What is normal WBC count?
4,000-11,000
Sudden fever, chills, sore throat, and weakness are symptoms of what condition?
agranulocytosis
How often is ANC monitored with clozapine?
Weekly x 6 months; Biweekly x 6 months; then Monthly
Should WBC count be obtained with clozapine?
No. Just ANC
Agranulocytosis, myocarditis, and seizures are side effects of what drug?
clozapine
What antipsychotic can cause sialorrhea hypersalivation
Clozapine
What is ANC in mild neutropenia?
1,000-2,000
What is ANC in moderate neutropenia?
500-1,000
What is ANC in agranulocytosis (severe neutropenia)?
<500
How long and how often must binge eating occur for bulimia nervosa and binge
eating disorder to be diagnosed?
at least once/week x 3 months
What is the % BMI in anorexia nervosa?
<85% of expected weight
How does Binge eating disorder differ from bulimia nervosa?
No compensatory behavior purging
Amenorrhea, VS bradycardia, hypotension, hypothermia, ECG changes, yellow
skin, lanugo, peripheral edema, emaciation are physical exam findings in which
disorder?
Anorexia
Russel's sign callus on dorsum of hand from vomiting, erosion of dental enamel,
hypertrophy of salivary glands, and normal weight are physical exam findings in
what disorder?
Bulimia
Electrolytes changes hypokalemia, hypomagnesemia, hypoglycemia, hematology
changes leukopenia, anemia, thrombocytopenia, and decreased LH and FSH are
present with which disorder?
Anorexia
Electrolytes changes hypokalemia, hypomagnesemia, hyponatremia,
hypochloremia, metabolic acidosis or alkalosis, and increased serum amylase are
present in which disorder?
Bulimia
What is the pharmacologic treatment of Bulimia Nervosa?
Fluoxetine prozac
