PEPTIC ULCER DISEASE EXAM WITH
100% CORRECT ANSWERS {GRADED
A+}
peptic ulcer disease - ✔✔a group of upper GI disorders
characterized by varying degrees of erosion of the gut wall
•Name two complications of PUD - ✔✔hemorrhage and
perforation
•Name two locations where peptic ulcers are most common -
✔✔lesser curvature of the stomach and duodenum
•When do peptic ulcers develop? - ✔✔when there is an
imbalance between mucosal defensive factors and aggressive
factors.
,•Name the two major defensive factors against ulceration. -
✔✔mucus and bicarbonate
•Name the four major aggressive factors for ulceration - ✔✔H.
pylori, NSAIDs, gastric acid, and pepsin
•Name the two most important agents that can weaken defenses
against ulceration - ✔✔H. pylori, NSAIDs
•Explain how prostaglandins play an important role in maintaining
defenses. - ✔✔stimulate secretion of mucus and bicarbonate;
promote vasodilation, which helps maintain submocosal blood
flow; and suppress secretion of gastric acid
Helicobacter pylori - ✔✔a gram negative bacillus that can
colonize the stomach and duodenum
•Explain how NSAIDs are the underlying cause of many gastric
ulcers and some duodenal ulcers. - ✔✔inhibit the biosynthesis of
prostaglandins
•True or False? Patients with gastric ulcers produce an increased
amount of gastric acid. - ✔✔False
, •Name one life-style habit that delays ulcer healing and increases
the risk of recurrence. - ✔✔smoking
•Name the first and second most common causes of gastric and
duodenal ulcers. - ✔✔H. pylori, NSAIDs
•Name four goals of drug therapy for PUD. - ✔✔(1) alleviate
symptoms, (2) promote healing, (3) prevent complications, and (4)
prevent recurrence.
•Name the five classes of antiulcer drugs. - ✔✔antibiotics,
antisecretory agents, mucosal protectants, antisecretory agents
that enhance mucosal defenses, and antacids
•Name the three basic ways drugs used for PUD act to promote
ulcer healing. Identify classes of drugs that perform each action. -
✔✔(1) eradicate H. pylori (anitbiotics), (2) reduce gastric acidity
(antisecretory agents, misoprostol, and antacids), and (3)
enhance mucosal defenses (sucralfate and misoprostol)
•Name the 2 preferred drug options for prevention of NSAID-
Induced Ulcers. - ✔✔misoprostol and the proton pump inhibitors
100% CORRECT ANSWERS {GRADED
A+}
peptic ulcer disease - ✔✔a group of upper GI disorders
characterized by varying degrees of erosion of the gut wall
•Name two complications of PUD - ✔✔hemorrhage and
perforation
•Name two locations where peptic ulcers are most common -
✔✔lesser curvature of the stomach and duodenum
•When do peptic ulcers develop? - ✔✔when there is an
imbalance between mucosal defensive factors and aggressive
factors.
,•Name the two major defensive factors against ulceration. -
✔✔mucus and bicarbonate
•Name the four major aggressive factors for ulceration - ✔✔H.
pylori, NSAIDs, gastric acid, and pepsin
•Name the two most important agents that can weaken defenses
against ulceration - ✔✔H. pylori, NSAIDs
•Explain how prostaglandins play an important role in maintaining
defenses. - ✔✔stimulate secretion of mucus and bicarbonate;
promote vasodilation, which helps maintain submocosal blood
flow; and suppress secretion of gastric acid
Helicobacter pylori - ✔✔a gram negative bacillus that can
colonize the stomach and duodenum
•Explain how NSAIDs are the underlying cause of many gastric
ulcers and some duodenal ulcers. - ✔✔inhibit the biosynthesis of
prostaglandins
•True or False? Patients with gastric ulcers produce an increased
amount of gastric acid. - ✔✔False
, •Name one life-style habit that delays ulcer healing and increases
the risk of recurrence. - ✔✔smoking
•Name the first and second most common causes of gastric and
duodenal ulcers. - ✔✔H. pylori, NSAIDs
•Name four goals of drug therapy for PUD. - ✔✔(1) alleviate
symptoms, (2) promote healing, (3) prevent complications, and (4)
prevent recurrence.
•Name the five classes of antiulcer drugs. - ✔✔antibiotics,
antisecretory agents, mucosal protectants, antisecretory agents
that enhance mucosal defenses, and antacids
•Name the three basic ways drugs used for PUD act to promote
ulcer healing. Identify classes of drugs that perform each action. -
✔✔(1) eradicate H. pylori (anitbiotics), (2) reduce gastric acidity
(antisecretory agents, misoprostol, and antacids), and (3)
enhance mucosal defenses (sucralfate and misoprostol)
•Name the 2 preferred drug options for prevention of NSAID-
Induced Ulcers. - ✔✔misoprostol and the proton pump inhibitors
