Naplex Practice Exam 2 Questions with 100%
Correct Answers
A patient has just returned from England, where she received a medication to treat her asthma. She
asks for the US equivalent for this medication. What is the best resource to identify this medication?
A: Facts and Comparisons
B: Martindales Extra Pharmacopoeia
C: Identidex
D: Physician ಬ s Desk Reference (PDR)
B: Martindales Extra Pharmacopoeia
Peritoneal dialysis is useful for removing drugs from an intoxicated person if the drug:
A: is polar.
B: is lipid soluble.
C: is highly bound to plasma proteins.
D: has a large apparent volume of distribution
A: is polar.
peritoneal dialysis is not practical for drugs that are highly bound to plasma or tissue proteins, are
lipid soluble, or have a large volume of distribution. Drugs that are polar and have a small apparent
volume of distribution tend to have a larger concentration in plasma and highly perfused tissues.
These polar drugs are more easily dialyzed in the case of drug intoxication.
The percentage of elemental iron in ferrous gluconate is:
A: 10%
B: 12%
C: 20%
D: 33%
B: 12%
Iron is available in different oral forms as ferrous gluconate, ferrous sulfate, and ferrous fumarate.
Each form has a different iron content. Ferrous gluconate contains 12% elemental iron, ferrous sulfate
20%, and ferrous fumarate 33%.
In the extemporaneous compounding of an ointment, the process of using a suitable nonsolvent to
reduce the particle size of a drug before its incorporation into the ointment is known as:
A: geometric dilution
B: levigation
C: pulverization by intervention
D: trituration
C: pulverization by intervention
In extemporaneous compounding various methods may be used to reduce the particle size of a drug,
including levigation, pulverization by intervention, and trituration. Geometric dilution is a method of
mixing a small amount of drug with a large amount of powder in the geometric progression so that
the final powder mixture is homogeneous. Pulverization by intervention uses the addition of
nonsolvent
,An antibiotic for IV infusion is supplied in 5-mL vials at a concentration of 5 mg/mL. How many vials
are required for an 80-kg patient who needs an adult dose at a suggested infusion rate of 2.5
mg/kg/hr for 6 hr?
A: 2
B: 3
C: 4
D: 5
D: 5
The total dose is 1200mg. Each 5-mL vial contains 250mg. 1200mg / 250 mg = 4.8 vials (5).
The bioavailability of a drug from an immediate-release tablet is most often related to the:
A: Disintegration of the tablet
B: Dissolution of the drug
C: Plasma protein binding of the drug
D: Size of the tablet
B: Dissolution of the drug
For most drugs with poor aqueous solubility, the dissolution rate (the rate at which the drug is
solubilized) is the ratelimiting step for systemic drug absorption. Disintegration is the fragmentation
of a solid dosage form into smaller pieces.
Which of the following is/are protease inhibitor(s) used in the treatment of HIV? Select all that apply.
A: Doravirine
B: Indinavir
C: Nelfinavir
D: Delavirdine
B: Indinavir
C: Nelfinavir
Amprenavir, Indinavir, and Nelfinavir are referred to as protease inhibitors and are used in the
treatment of HIV infection in combination with other groups of antiretroviral agents. Delavirdine is
referred to as a nonnucleoside reverse transcriptase inhibitor and is used in the treatment of HIV as
well.
The rate of dissolution of a weak acid drug may be increased by:
A: Increasing the pH of the medium
B: Increasing the particle size of the solid drug
C: Decreasing the temperature of the medium
D: Increasing the viscosity of the medium
A: Increasing the pH of the medium
An increase in the pH of the medium will make the medium more alkaline, and the weak acid will
convert to the ionized species, becoming more water soluble. Increasing the particle size decreases
the effective surface area of the solid drug. Decreasing the temperature gives molecules less kinetic
energy, decreasing motion of the molecules. Increasing the viscosity of the medium slows the
diffusion of drug molecules into the solvent.
, BH is a 29yoM with a primary diagnosis of bipolar disorder. Which of the following is true about his
primary diagnosis? Select all that apply.
A: Two common symptoms of bipolar disorder are hallucinations and delusions
B: The subcategories for bipolar disorder are bipolar I disorder and bipolar II disorder
C: Mood stabilizers have historically been the mainstays of therapy for this condition
D: Bipolar disorder only effects adults
B: The subcategories for bipolar disorder are bipolar I disorder and bipolar II disorder
C: Mood stabilizers have historically been the mainstays of therapy for this condition
The further classifications of bipolar disorder relate to the type and frequency of hypomanic, manic,
and depressive episodes. Mood stabilizers ದ lithium, valproic acid, and carbamazepine ದ have
historically been the mainstays of therapy. Bipolar disorder can affect children, teens, and adults.
Hallucinations and delusions are symptoms of schizophrenia
Lithium is:
A: the drug of choice for the acute and maintenance treatment of mania and hypomania
B: classified as an anxiolytic
C: a serum electrolyte similar to sodium and is relatively free of serious adverse effects and drug
interactions
D: commonly used as an antidepressant
A: the drug of choice for the acute and maintenance treatment of mania and hypomania
Lithium is the drug of choice for the acute and maintenance treatment of mania and hypomania.
Membrane stabilization, inhibition of norepinephrine release, accelerated norepinephrine
metabolism, increased presynaptic reuptake of norepinephrine and serotonin, and decreased
receptor sensitivity appear to be therapeutic properties of lithium.
The MW of lithium carbonate, Li2CO3, is 73.29. How many milliequivalents of lithium are there in a
300mg tablet of lithium carbonate?
A: 1.24
B: 2.46
C: 4.06
D: 8.12
D: 8.12
Equivalent weight (Li2CO3) = molecular weight/valence = 73.89/2 = 36.945 Milliequivalents = drug
(mg)/equivalent weight (mg) = 300/36.945 = 8.12 mEq
BH is a 29yoM with a PMH of bipolar disorder who was admitted to the hospital for an acute manic
episode. The admitting physician suspects that BH has been noncompliant with his lithium therapy
prior to admission. When interpreting the admission lithium level, the physician should consider:
Select all that apply
A: The sample draw time with respect to the time of the last scheduled lithium dose
B: Concomitant drug therapy
C: The acute manic condition of the patient
D: How much time the patient exercises per week
A: The sample draw time with respect to the time of the last scheduled lithium dose
B: Concomitant drug therapy
C: The acute manic condition of the patient
Correct Answers
A patient has just returned from England, where she received a medication to treat her asthma. She
asks for the US equivalent for this medication. What is the best resource to identify this medication?
A: Facts and Comparisons
B: Martindales Extra Pharmacopoeia
C: Identidex
D: Physician ಬ s Desk Reference (PDR)
B: Martindales Extra Pharmacopoeia
Peritoneal dialysis is useful for removing drugs from an intoxicated person if the drug:
A: is polar.
B: is lipid soluble.
C: is highly bound to plasma proteins.
D: has a large apparent volume of distribution
A: is polar.
peritoneal dialysis is not practical for drugs that are highly bound to plasma or tissue proteins, are
lipid soluble, or have a large volume of distribution. Drugs that are polar and have a small apparent
volume of distribution tend to have a larger concentration in plasma and highly perfused tissues.
These polar drugs are more easily dialyzed in the case of drug intoxication.
The percentage of elemental iron in ferrous gluconate is:
A: 10%
B: 12%
C: 20%
D: 33%
B: 12%
Iron is available in different oral forms as ferrous gluconate, ferrous sulfate, and ferrous fumarate.
Each form has a different iron content. Ferrous gluconate contains 12% elemental iron, ferrous sulfate
20%, and ferrous fumarate 33%.
In the extemporaneous compounding of an ointment, the process of using a suitable nonsolvent to
reduce the particle size of a drug before its incorporation into the ointment is known as:
A: geometric dilution
B: levigation
C: pulverization by intervention
D: trituration
C: pulverization by intervention
In extemporaneous compounding various methods may be used to reduce the particle size of a drug,
including levigation, pulverization by intervention, and trituration. Geometric dilution is a method of
mixing a small amount of drug with a large amount of powder in the geometric progression so that
the final powder mixture is homogeneous. Pulverization by intervention uses the addition of
nonsolvent
,An antibiotic for IV infusion is supplied in 5-mL vials at a concentration of 5 mg/mL. How many vials
are required for an 80-kg patient who needs an adult dose at a suggested infusion rate of 2.5
mg/kg/hr for 6 hr?
A: 2
B: 3
C: 4
D: 5
D: 5
The total dose is 1200mg. Each 5-mL vial contains 250mg. 1200mg / 250 mg = 4.8 vials (5).
The bioavailability of a drug from an immediate-release tablet is most often related to the:
A: Disintegration of the tablet
B: Dissolution of the drug
C: Plasma protein binding of the drug
D: Size of the tablet
B: Dissolution of the drug
For most drugs with poor aqueous solubility, the dissolution rate (the rate at which the drug is
solubilized) is the ratelimiting step for systemic drug absorption. Disintegration is the fragmentation
of a solid dosage form into smaller pieces.
Which of the following is/are protease inhibitor(s) used in the treatment of HIV? Select all that apply.
A: Doravirine
B: Indinavir
C: Nelfinavir
D: Delavirdine
B: Indinavir
C: Nelfinavir
Amprenavir, Indinavir, and Nelfinavir are referred to as protease inhibitors and are used in the
treatment of HIV infection in combination with other groups of antiretroviral agents. Delavirdine is
referred to as a nonnucleoside reverse transcriptase inhibitor and is used in the treatment of HIV as
well.
The rate of dissolution of a weak acid drug may be increased by:
A: Increasing the pH of the medium
B: Increasing the particle size of the solid drug
C: Decreasing the temperature of the medium
D: Increasing the viscosity of the medium
A: Increasing the pH of the medium
An increase in the pH of the medium will make the medium more alkaline, and the weak acid will
convert to the ionized species, becoming more water soluble. Increasing the particle size decreases
the effective surface area of the solid drug. Decreasing the temperature gives molecules less kinetic
energy, decreasing motion of the molecules. Increasing the viscosity of the medium slows the
diffusion of drug molecules into the solvent.
, BH is a 29yoM with a primary diagnosis of bipolar disorder. Which of the following is true about his
primary diagnosis? Select all that apply.
A: Two common symptoms of bipolar disorder are hallucinations and delusions
B: The subcategories for bipolar disorder are bipolar I disorder and bipolar II disorder
C: Mood stabilizers have historically been the mainstays of therapy for this condition
D: Bipolar disorder only effects adults
B: The subcategories for bipolar disorder are bipolar I disorder and bipolar II disorder
C: Mood stabilizers have historically been the mainstays of therapy for this condition
The further classifications of bipolar disorder relate to the type and frequency of hypomanic, manic,
and depressive episodes. Mood stabilizers ದ lithium, valproic acid, and carbamazepine ದ have
historically been the mainstays of therapy. Bipolar disorder can affect children, teens, and adults.
Hallucinations and delusions are symptoms of schizophrenia
Lithium is:
A: the drug of choice for the acute and maintenance treatment of mania and hypomania
B: classified as an anxiolytic
C: a serum electrolyte similar to sodium and is relatively free of serious adverse effects and drug
interactions
D: commonly used as an antidepressant
A: the drug of choice for the acute and maintenance treatment of mania and hypomania
Lithium is the drug of choice for the acute and maintenance treatment of mania and hypomania.
Membrane stabilization, inhibition of norepinephrine release, accelerated norepinephrine
metabolism, increased presynaptic reuptake of norepinephrine and serotonin, and decreased
receptor sensitivity appear to be therapeutic properties of lithium.
The MW of lithium carbonate, Li2CO3, is 73.29. How many milliequivalents of lithium are there in a
300mg tablet of lithium carbonate?
A: 1.24
B: 2.46
C: 4.06
D: 8.12
D: 8.12
Equivalent weight (Li2CO3) = molecular weight/valence = 73.89/2 = 36.945 Milliequivalents = drug
(mg)/equivalent weight (mg) = 300/36.945 = 8.12 mEq
BH is a 29yoM with a PMH of bipolar disorder who was admitted to the hospital for an acute manic
episode. The admitting physician suspects that BH has been noncompliant with his lithium therapy
prior to admission. When interpreting the admission lithium level, the physician should consider:
Select all that apply
A: The sample draw time with respect to the time of the last scheduled lithium dose
B: Concomitant drug therapy
C: The acute manic condition of the patient
D: How much time the patient exercises per week
A: The sample draw time with respect to the time of the last scheduled lithium dose
B: Concomitant drug therapy
C: The acute manic condition of the patient
