Module 4 - Lecture 1 - Asthma

Module 4 - Lecture 1 - Asthma
Asthma - CORRECT ANSWER-Chronic inflammatory disorder of the bronchial
mucosa

Manifestations of asthma - CORRECT ANSWER-Thick mucus (goblet cell
hyperplasia)
Mucosal edema
Bronchial hyperconstriction
Dyspnea
Non-productive cough
Tachycardia
Tachypnea
Hypoxemia
Respiratory acidosis (can blow off the CO2)
Respiratory alkalosis (hyperventilation)

Asthma Pathogenesis - CORRECT ANSWER-Dendritic APCs to Th -> Th
release IL's and enhance IgE production -> IgE's promote mast cell
degranulation (bronchospasm) -> IL's promote eosinophil degranulation (fibrosis,
tissue damage)

Sensitization - CORRECT ANSWER-Airway epithelial cells activated by antigens
or damaged.

Secretion from airway put dendritic cells on high alert

Dendritic cells process antigens and display via MHC II to T cells in lymph nodes

T-cell activation (antibody production, activation and proliferation of other immune
cells).

Activation upon re-exposure - CORRECT ANSWER-Airway epithelial cells
activated by antigens or damage.

secretion from ECs put DCs on high alert.