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allows identification of -important groups involved in binding -pharmacophore - Answer analogues esters more likely to be important for ___reasons - Answer pharmacokinetic in SAR, ___ tests binding interactions w/ a target - Answer in virtro in SAR if ___ activity is unaffected, it implies group isn't important - Answer in vivo amide N is poor___ and so this eliminates___ interactions - Answer HBA when an amide is formed from an amine___ is eliminated - Answer HBD in SAR, ___ tests for target binding interactions and or pharmacokinetics - Answer in vivo SAR on carboxylic acids___ removes carbonyl oxygen as potential HBA & prevents ionization - Answer reduction possible binding interactions for ketones - Answer dipole-dipole & H-bonding easiest analogues to make are those made from the ____ - Answer lead compound SAR on carboxylic acids _____prevents ionizations, HBD interactions and may hinder HBA by steric effect - Answer esterification