Test Bank - Focus on Nursing Pharmacology (8th Edition by Karch)
1. A 32-year-old female patient is admitted to the floor with a superinfection. Her
orders read tigecycline (Tygacil) 100 mg IV followed by 50 mg IV every 12 hours
infused over 30 to 60 minutes for 5 days. What would be important for the nurse to
educate this patient about?
a. Analgesics
b. Antihistamines
c. Contraceptives
d. Decongestants
Ans: C
Feedback:
Many antibiotics interfere with the effectiveness of oral contraceptives and unplanned
pregnancies can occur. Women should be advised to use a barrier form of
contraceptives when taking this drug. No known serious drug interactions involve
analgesics, antihistamines, or decongestants.
2. A patient with a gram-negative infection is being treated with an aminoglycoside.
What system should the nurse expect to monitor closely while the patient is taking
this medication?
a. Respiratory system
b. Ophthalmic system
c. Renal system
d. Musculoskeletal system
Ans: C
Feedback:
Renal function should be tested daily because aminoglycosides depend on the kidney
for excretion and if the glomerular filtration rate (GFR) is abnormal it may be toxic to
the kidney. The results of the renal function testing could change the daily dosage.
Aminoglycosides do not usually adversely affect respiratory, hepatic, or
musculoskeletal function, although baseline data concerning these systems is always
needed.
3. How would the nurse describe selective toxicity?
a. Selective toxicity interferes with a biochemical reaction common to many
different organisms.
b. Selective toxicity will decrease invading bacteria by interfering with the
pathogens’ ability to reproduce.
, c. Selective toxicity will eliminate bacteria by interrupting protein synthesis
and damaging the pathogen’s cell wall.
d. Selective toxicity is the ability of the drug to kill foreign cells without
causing harm to one’s own body cells.
Ans: D
Feedback:
The choice of antibiotics in a clinical situation is determined by assessing which drug
will affect the causative organism and lead to the fewest adverse effects. Selective
toxicity is the ability of the drug to kill foreign cells without causing harm to the
human body cells. How the antibiotic works to kill bacteria varies by drug type and
may reduce the ability to reproduce, damage the cell wall, or interfere with a
biochemical reaction, but this is a description of how the antibiotic works and does
not describe selective toxicity
4. A local bioterrorism medical team is learning about germ warfare. The team is
instructed that a fluoroquinolone may be used to prevent an outbreak of anthrax
infection. What fluoroquinolone would the nurse be most likely to administer for
this purpose?
a. Ciprofloxacin (Cipro)
b. Gemifloxacin (Factive)
c. Norfloxacin (Noroxin)
d. Sparfloxacin (Zagam)
Ans: A
Feedback:
Ciprofloxacin (Cipro) is the most widely used fluoroquinolone and is indicated for the
prevention of anthrax infection. Gemifloxacin and sparfloxacin are most useful in
treating acute episodes of chronic bronchitis and community-acquired pneumonia.
Norfloxacin is recommended only for certain types of urinary tract infections.
5. A clinic nurse is caring for a 66-pound child who has acute otitis media. The
physician has ordered ceftibuten (Cedax) 9 mg/kg per day PO for 10 days. The
drug comes in an oral suspension of 90 mg/5 mL. How many mL will the nurse
administer?
a. 5 mL
b. 10 mL
c. 15 mL
d. 20 mL
Ans: C
Feedback:
First, using the formula: 2.2 lb/1 kg = 66 lb/X kg, determine the child’s weight in kg
(66/2.2 = 30 kg). Next, determine the desired dose by using the formula: amount of
1. A 32-year-old female patient is admitted to the floor with a superinfection. Her
orders read tigecycline (Tygacil) 100 mg IV followed by 50 mg IV every 12 hours
infused over 30 to 60 minutes for 5 days. What would be important for the nurse to
educate this patient about?
a. Analgesics
b. Antihistamines
c. Contraceptives
d. Decongestants
Ans: C
Feedback:
Many antibiotics interfere with the effectiveness of oral contraceptives and unplanned
pregnancies can occur. Women should be advised to use a barrier form of
contraceptives when taking this drug. No known serious drug interactions involve
analgesics, antihistamines, or decongestants.
2. A patient with a gram-negative infection is being treated with an aminoglycoside.
What system should the nurse expect to monitor closely while the patient is taking
this medication?
a. Respiratory system
b. Ophthalmic system
c. Renal system
d. Musculoskeletal system
Ans: C
Feedback:
Renal function should be tested daily because aminoglycosides depend on the kidney
for excretion and if the glomerular filtration rate (GFR) is abnormal it may be toxic to
the kidney. The results of the renal function testing could change the daily dosage.
Aminoglycosides do not usually adversely affect respiratory, hepatic, or
musculoskeletal function, although baseline data concerning these systems is always
needed.
3. How would the nurse describe selective toxicity?
a. Selective toxicity interferes with a biochemical reaction common to many
different organisms.
b. Selective toxicity will decrease invading bacteria by interfering with the
pathogens’ ability to reproduce.
, c. Selective toxicity will eliminate bacteria by interrupting protein synthesis
and damaging the pathogen’s cell wall.
d. Selective toxicity is the ability of the drug to kill foreign cells without
causing harm to one’s own body cells.
Ans: D
Feedback:
The choice of antibiotics in a clinical situation is determined by assessing which drug
will affect the causative organism and lead to the fewest adverse effects. Selective
toxicity is the ability of the drug to kill foreign cells without causing harm to the
human body cells. How the antibiotic works to kill bacteria varies by drug type and
may reduce the ability to reproduce, damage the cell wall, or interfere with a
biochemical reaction, but this is a description of how the antibiotic works and does
not describe selective toxicity
4. A local bioterrorism medical team is learning about germ warfare. The team is
instructed that a fluoroquinolone may be used to prevent an outbreak of anthrax
infection. What fluoroquinolone would the nurse be most likely to administer for
this purpose?
a. Ciprofloxacin (Cipro)
b. Gemifloxacin (Factive)
c. Norfloxacin (Noroxin)
d. Sparfloxacin (Zagam)
Ans: A
Feedback:
Ciprofloxacin (Cipro) is the most widely used fluoroquinolone and is indicated for the
prevention of anthrax infection. Gemifloxacin and sparfloxacin are most useful in
treating acute episodes of chronic bronchitis and community-acquired pneumonia.
Norfloxacin is recommended only for certain types of urinary tract infections.
5. A clinic nurse is caring for a 66-pound child who has acute otitis media. The
physician has ordered ceftibuten (Cedax) 9 mg/kg per day PO for 10 days. The
drug comes in an oral suspension of 90 mg/5 mL. How many mL will the nurse
administer?
a. 5 mL
b. 10 mL
c. 15 mL
d. 20 mL
Ans: C
Feedback:
First, using the formula: 2.2 lb/1 kg = 66 lb/X kg, determine the child’s weight in kg
(66/2.2 = 30 kg). Next, determine the desired dose by using the formula: amount of
