IMMUNODEFICIENCY AND AUTOIMMUNITY
Immunopathology >>answer>>The study of disease states associated with over or under-active immune
response
Immunodeficiency >>answer>>Reduced or no functional immune response
Autoimmunity >>answer>>immune response mis-targeted against "self"
Hypersensitivity >>answer>>Acceptable but over-exaggerated immune response
Primary Immunodeficiency >>answer>> from a genetic resulting c defect
Secondary Immunodeficiency >>answer>>"acquired", resulting from an environmental cause (viral
infection, cancer, etc.)
Congenital Immunodeficiency >>answer>>Naturally occurring genetic errors/defects
- innate immune deficiencies
- defect of lymphocyte maturation
- defect of lymphocyte activation or function
Can be mild or life-threatening
Hallmarked by increases susceptibility to infectious diseases
- Can symptoms tell us root of cause?
T-Cell Deficiencies >>answer>>May be reduced T cell zones in lymphoid organs
Reduced DTH reactions to common antigens
, Defective T cell proliferative responses to mitogens in vitro
Consequences:
- viral and other intracellular microbial infections
* pneumocystis jiroveci, atypical mycobacteria, lungi
- virus-associated malignancies
* EBV-associated lymphomas
B-Cell Deficiencies >>answer>>- Absent or reduced follicles and terminal centers in lymphoid organs
- Reduced serum Ig levels
Consequences:
- Pyogenic bacterial infections
Innate Immune deficiencies >>answer>>-Variable, depending on which component of innate immunity is
defective
Consequences:
- Variable, pyogenic bacterial infections
Lymphocyte Maturation Immunodeficiencies >>answer>>- SCID
- Bruton's Agammaglobulinemia
- DiGeorge's Syndrome
SCID >>answer>>Sever Combined Immunodeficiency
- No B or T cells
- Bubble Boy
- Mutations in RAG recombinase leads to (+) selection failure
Immunopathology >>answer>>The study of disease states associated with over or under-active immune
response
Immunodeficiency >>answer>>Reduced or no functional immune response
Autoimmunity >>answer>>immune response mis-targeted against "self"
Hypersensitivity >>answer>>Acceptable but over-exaggerated immune response
Primary Immunodeficiency >>answer>> from a genetic resulting c defect
Secondary Immunodeficiency >>answer>>"acquired", resulting from an environmental cause (viral
infection, cancer, etc.)
Congenital Immunodeficiency >>answer>>Naturally occurring genetic errors/defects
- innate immune deficiencies
- defect of lymphocyte maturation
- defect of lymphocyte activation or function
Can be mild or life-threatening
Hallmarked by increases susceptibility to infectious diseases
- Can symptoms tell us root of cause?
T-Cell Deficiencies >>answer>>May be reduced T cell zones in lymphoid organs
Reduced DTH reactions to common antigens
, Defective T cell proliferative responses to mitogens in vitro
Consequences:
- viral and other intracellular microbial infections
* pneumocystis jiroveci, atypical mycobacteria, lungi
- virus-associated malignancies
* EBV-associated lymphomas
B-Cell Deficiencies >>answer>>- Absent or reduced follicles and terminal centers in lymphoid organs
- Reduced serum Ig levels
Consequences:
- Pyogenic bacterial infections
Innate Immune deficiencies >>answer>>-Variable, depending on which component of innate immunity is
defective
Consequences:
- Variable, pyogenic bacterial infections
Lymphocyte Maturation Immunodeficiencies >>answer>>- SCID
- Bruton's Agammaglobulinemia
- DiGeorge's Syndrome
SCID >>answer>>Sever Combined Immunodeficiency
- No B or T cells
- Bubble Boy
- Mutations in RAG recombinase leads to (+) selection failure
