T-CELL MEDIATED IMMUNITY EXAM
WITH COMPLETE QUESTIONS AND
ANSWERS { GRADED A+}
Adaptive Immunity - ✔✔refers to antigen-specific defense
mechanisms; develops throughout life; two major branches include
humoral immunity (B cells) and cell-mediated immunity (T cells)
Cell-Mediated Immunity - ✔✔protects the host by activating
phagocytic macrophages, natural killer cells and cytotoxic T cells to
destroy virus infected cells, intracellular bacterial, cancer cells
displaying tumor antigens; cells stimulating this response secrete a
variety of cytokines
Activation of Naive T Cells - ✔✔activation and clonal expansion
occurs upon first encounter with the antigen in the lymph nodes;
, controlled by a variety of signals including the peptide:MHC complex,
co-stimulatory molecules and cytokines
Dendritic Cells - ✔✔most important antigen presenting cell for the
activation of naive T cells in secondary lymphoid organs
IL-2 - ✔✔resting T cells express only a moderate-affinity IL-2 receptor
for beta and gamma chains while activated T cells express a high-
affinity IL-2 receptor of beta and gamma chains while secreting IL-2;
binding of IL-2 to its receptor promotes accelerated cell cycling; IL-2
modulates T-cell differentiation and enhances proliferation
APC Signals to Naive T Cells - ✔✔1. activation by binding of MHC
molecules leads to cell activation
2. instincts of survival by B7 binding to CD28
3. cytokines signal for T cell differentiation promoting different
functions
WITH COMPLETE QUESTIONS AND
ANSWERS { GRADED A+}
Adaptive Immunity - ✔✔refers to antigen-specific defense
mechanisms; develops throughout life; two major branches include
humoral immunity (B cells) and cell-mediated immunity (T cells)
Cell-Mediated Immunity - ✔✔protects the host by activating
phagocytic macrophages, natural killer cells and cytotoxic T cells to
destroy virus infected cells, intracellular bacterial, cancer cells
displaying tumor antigens; cells stimulating this response secrete a
variety of cytokines
Activation of Naive T Cells - ✔✔activation and clonal expansion
occurs upon first encounter with the antigen in the lymph nodes;
, controlled by a variety of signals including the peptide:MHC complex,
co-stimulatory molecules and cytokines
Dendritic Cells - ✔✔most important antigen presenting cell for the
activation of naive T cells in secondary lymphoid organs
IL-2 - ✔✔resting T cells express only a moderate-affinity IL-2 receptor
for beta and gamma chains while activated T cells express a high-
affinity IL-2 receptor of beta and gamma chains while secreting IL-2;
binding of IL-2 to its receptor promotes accelerated cell cycling; IL-2
modulates T-cell differentiation and enhances proliferation
APC Signals to Naive T Cells - ✔✔1. activation by binding of MHC
molecules leads to cell activation
2. instincts of survival by B7 binding to CD28
3. cytokines signal for T cell differentiation promoting different
functions
