1
DRUGS USED IN DISORDERS OF COAGULATION
BLOOD COAGULATION
THROMBIN
● Proteolytically cleaves small peptides from fibrinogen, allowing fibrinogen to polymerize and form a fibrin clot
● Also activates many upstream clotting factors, leading to more thrombin generation, and activates factor XIII, a transaminase that cross-links the fibrin polymer and stabilizes
the clot
● Potent platelet activator and mitogen
● Also exerts anticoagulant effects by activating the protein C pathway, which attenuates the clotting response
FIBRINOLYSIS
● Refers to the process of fibrin digestion by the fibrin-specific protease, plasmin
● Fibrinolytic system is similar to the coagulation system in that the precursor form of the serine protease plasmin circulates in an inactive form as plasminogen
AJA
, 2
AJA
DRUGS USED IN DISORDERS OF COAGULATION
BLOOD COAGULATION
THROMBIN
● Proteolytically cleaves small peptides from fibrinogen, allowing fibrinogen to polymerize and form a fibrin clot
● Also activates many upstream clotting factors, leading to more thrombin generation, and activates factor XIII, a transaminase that cross-links the fibrin polymer and stabilizes
the clot
● Potent platelet activator and mitogen
● Also exerts anticoagulant effects by activating the protein C pathway, which attenuates the clotting response
FIBRINOLYSIS
● Refers to the process of fibrin digestion by the fibrin-specific protease, plasmin
● Fibrinolytic system is similar to the coagulation system in that the precursor form of the serine protease plasmin circulates in an inactive form as plasminogen
AJA
, 2
AJA
